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Anti-encephalitogenic effects of cucumber leaf extract
dc.creator | Jevtić, Bojan | |
dc.creator | Nikolovski, Neda | |
dc.creator | Stanisavljević, Suzana | |
dc.creator | Gašić, Uroš | |
dc.creator | Mišić, Danijela | |
dc.creator | Despotović, Jovana | |
dc.creator | Samardžić, Jelena | |
dc.creator | Miljković, Đorđe | |
dc.creator | Timotijević, Gordana | |
dc.date.accessioned | 2017-11-23T11:27:51Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S1756464617304486 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2832 | |
dc.description.abstract | Cucumber (Cucumis sativus) fruit has been used in cuisine worldwide, while its leaves are rich in immunomodulatory compounds. Cucumber leaf extract (CLE) was characterized by the predominance of triterpenoids cucurbitacins and significant levels of phenolics. Effects of CLE on CD4 + T helper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system were investigated in our study. CLE potently inhibited production of major pathogenic Th cytokines: interferon-gamma and interleukin-17, as well as of nitric oxide and reactive oxygen species in macrophages. Antigen-presenting activity of macrophages and dendritic cells was also affected by CLE. The effects of CLE were co-incident with modulation of NFκB and p38 MAPK signaling. Concentrations of CLE used in vitro did not show toxic effects on zebrafish embryos. Moreover, CLE inhibited generation of encephalitogenic cells in vivo. These results demonstrate that CLE deserve further investigation on its anti-encephalitogenic therapeutic properties. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173005/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173024/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Functional Foods | |
dc.subject | Cucumber | |
dc.subject | Cucurbitacin | |
dc.subject | T cell | |
dc.subject | Macrophage | |
dc.subject | Autoimmunity | |
dc.subject | Experimental autoimmune encephalomyelitis | |
dc.title | Anti-encephalitogenic effects of cucumber leaf extract | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јевтић, Бојан; Гашић, Урош; Самарджић, Јелена; Деспотовић, Јована; Тимотијевић, Гордана; Станисављевић, Сузана; Ђедовић, Неда; Миљковић, Ђорђе; Мишић, Данијела; | |
dc.rights.holder | © 2017 Elsevier Ltd. | |
dc.citation.volume | 37 | |
dc.description.other | Journal of Functional Foods (2017), 37: 249-262 | |
dc.identifier.doi | 10.1016/j.jff.2017.07.060 | |
dc.identifier.scopus | 2-s2.0-85026788295 | |
dc.identifier.wos | 000412863400025 | |
dc.citation.apa | Jevtić, B., Djedović, N., Stanisavljević, S., Gašić, U., Mišić, D., Despotović, J., Samardžić, J., et al. (2017). Anti-encephalitogenic effects of cucumber leaf extract. Journal of Functional Foods, 37, 249–262. | |
dc.citation.vancouver | Jevtić B, Djedović N, Stanisavljević S, Gašić U, Mišić D, Despotović J, Samardžić J, Miljković D, Timotijević G. Anti-encephalitogenic effects of cucumber leaf extract. J Funct Foods. 2017;37:249–62. | |
dc.citation.spage | 249 | |
dc.citation.epage | 262 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |