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Strain-specific helper T cell profile in the gut-associated lymphoid tissue
dc.creator | Stanisavljević, Suzana | |
dc.creator | Nikolovski, Neda | |
dc.creator | Vujičić, Milica | |
dc.creator | Saksida, Tamara | |
dc.creator | Jevtić, Bojan | |
dc.creator | Milovanović, Boško | |
dc.creator | Momčilović, Miljana | |
dc.creator | Miljković, Đorđe | |
dc.creator | Stojanović, Ivana D. | |
dc.date.accessioned | 2017-11-23T11:04:58Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.issn | 165-2478 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S0165247817301979 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2854 | |
dc.description.abstract | C57BL/6, BALB/c and NOD mice are among the most frequently used strains in autoimmunity research. NOD mice spontaneously develop type 1 diabetes (T1D) and they are prone to induction of experimental autoimmune encephalomyelitis (EAE). Both diseases can be routinely induced in C57BL/6 mice, but not in BALB/c mice. Also, C57BL/6 mice are generally considered T helper (Th)1-biased and BALB/c Th2-biased mice. Having in mind increasingly appreciated role of gut associated lymphoid tissue (GALT) cells in autoimmunity, especially in relation to gut Th17 and regulatory T (Treg) cells, our aim was to determine if there are differences in proportion of CD4 + T cell populations in mesenteric lymph nodes and Peyer's p atches of these mouse strains. Lower proportion of Treg was observed in NOD PP, Th2 cells dominated in BALB/c mice in mesenteric lymph nodes (MLN) and Peyer's patches (PP), while Th1 cells prevailed in C57BL/6 MLN. Intradermal immunization of mice with complete Freund's adjuvant resulted in significant difference in Th cell distribution in GALT of NOD mice. Differences were less pronounced in C57BL/6 mice, while GALT of BALB/c mice was almost unresponsive to the immunization. The observed strain- and tissue-dependent changes in Treg proportion after the immunization was probably a consequence of different CCR2 or CCR6-related migration patterns and/or in situ Treg proliferation. In conclusion, NOD, a highly autoimmunity-prone mouse strain, exhibits more profound GALT-related immune response upon immunization compared to the strains that are less prone to autoimmunity. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Immunology Letters | |
dc.subject | Type 1 diabetes | |
dc.subject | Multiple sclerosis | |
dc.subject | Autoimmunity | |
dc.subject | Gut-associated lymphoid tissue | |
dc.subject | Immunization | |
dc.title | Strain-specific helper T cell profile in the gut-associated lymphoid tissue | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саксида, Тамара; Станисављевић, Сузана; Стојановић, Ивана; Ђедовић, Неда; Јевтић, Бојан; Момчиловић, Миљана; Миљковић, Ђорђе; Миловановић, Бошко; Вујичић, Милица; | |
dc.rights.holder | © 2017 European Federation of Immunological Societies | |
dc.citation.volume | 190 | |
dc.description.other | Immunology Letters (2017), 190: 282-288 | |
dc.identifier.doi | 10.1016/j.imlet.2017.08.017 | |
dc.identifier.pmid | 28851631 | |
dc.identifier.scopus | 2-s2.0-85029008926 | |
dc.identifier.wos | 000412963500035 | |
dc.citation.vancouver | Stanisavljević S, Đedović N, Vujičić M, Saksida T, Jevtić B, Milovanović B, Momčilović M, Miljković Đ, Stojanović I. Strain-specific helper T cell profile in the gut-associated lymphoid tissue. Immunol Lett. 2017;190:282–8. | |
dc.citation.spage | 282 | |
dc.citation.epage | 288 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 |