The role of nitric oxide in diabetic skin (patho)physiology
2018
Аутори:
Stančić, AnaJanković, Aleksandra
Korać, Aleksandra
Buzadžić, Biljana
Otašević, Vesna
Korać, Bato
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2017 Published by Elsevier Ireland Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
The role of nitric oxide (NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Various metabolic/biochemical and immunological dysregulations in diabetic skin are tightly coupled with the disturbances in the redox state, primarily the ratio between NO and superoxide (O(cyrillic) 2 - ). This review describes possible therapeutic significance of different redox state modulators in the treatment of diabetic skin disorders. The focus is on those modulators that tightly control NO/O(cyrillic) 2 - ratio through the complex mechanisms affecting endogenous NO and O(cyrillic) 2 - producing and removing systems. The fact that classic antioxidants failed to show significant benefits in diabetes, emphasizes the importance of such redox mechanism-based and targeted approaches.
Кључне речи:
Nitric oxide; Skin; Diabetes; l-arginine; SOD mimicИзвор:
Mechanisms of Ageing and Development, 2018, 172, 21-29Финансирање / пројекти:
- Улога реактивних врста кисеоника и азота у репродукцији: могућа примена у лечењу хуманог стерилитета (RS-MESTD-Basic Research (BR or ON)-173054)
- Бело или/и мрко: значај масног ткива у одржању укупне редокс зависне метаболичке контроле у физиолошким адаптацијама и метаболичким поремећајима (RS-MESTD-Basic Research (BR or ON)-173055)
DOI: 10.1016/j.mad.2017.08.018
PubMed: 28865932
WoS: 000436650700004
Scopus: 2-s2.0-85029625773
URI
http://linkinghub.elsevier.com/retrieve/pii/S0047637417301252https://radar.ibiss.bg.ac.rs/handle/123456789/2859