The role of nitric oxide in diabetic skin (patho)physiology
2018
Autori:
Stančić, AnaJanković, Aleksandra
Korać, Aleksandra
Buzadžić, Biljana
Otašević, Vesna
Korać, Bato
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2017 Published by Elsevier Ireland Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The role of nitric oxide (NO) in cutaneous physiology/pathology became a growing research field since the discovery that almost all types of skin cells can synthetize this redox signaling molecule about 20 years ago. Now, it is evident that NO is an important player in skin physiological processes and in responses of cutaneous cells to external insults, while the impaired NO signaling has an important consequence in skin pathology. Skin disorders are common complications in diabetic conditions. Various metabolic/biochemical and immunological dysregulations in diabetic skin are tightly coupled with the disturbances in the redox state, primarily the ratio between NO and superoxide (O(cyrillic) 2 - ). This review describes possible therapeutic significance of different redox state modulators in the treatment of diabetic skin disorders. The focus is on those modulators that tightly control NO/O(cyrillic) 2 - ratio through the complex mechanisms affecting endogenous NO and O(cyrillic) 2 - producing and removing systems. The fact that classic antioxidants failed to show significant benefits in diabetes, emphasizes the importance of such redox mechanism-based and targeted approaches.
Ključne reči:
Nitric oxide; Skin; Diabetes; l-arginine; SOD mimicIzvor:
Mechanisms of Ageing and Development, 2018, 172, 21-29Finansiranje / projekti:
- Uloga reaktivnih vrsta kiseonika i azota u reprodukciji: moguća primena u lečenju humanog steriliteta (RS-MESTD-Basic Research (BR or ON)-173054)
- Belo ili/i mrko: značaj masnog tkiva u održanju ukupne redoks zavisne metaboličke kontrole u fiziološkim adaptacijama i metaboličkim poremećajima (RS-MESTD-Basic Research (BR or ON)-173055)
DOI: 10.1016/j.mad.2017.08.018
PubMed: 28865932
WoS: 000436650700004
Scopus: 2-s2.0-85029625773
URI
http://linkinghub.elsevier.com/retrieve/pii/S0047637417301252https://radar.ibiss.bg.ac.rs/handle/123456789/2859