Oral administration of probiotic Lactobacillus paraplantarum BGCG11 attenuates diabetes-induced liver and kidney damage in rats
2017
Autori:
Mihailović, MirjanaŽivković, Milica
Arambašić Jovanović, Jelena
Tolinački, Maja
Đorđević, Marija
Rajić, Jovana
Uskoković, Aleksandra
Dinić, Svetlana
Grdović, Nevena
Golić, Nataša
Vidaković, Melita
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2017 Elsevier Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The aim of this study was to assess the effect of the probiotic Lactobacillus paraplantarum BGCG11 on the regulatory pathways that underlie the defense responses of the liver and kidney in diabetic rats. Probiotic-treated diabetic rats exhibited decreased hyperglycemia, glycated hemoglobin, triacylglycerols and a reduction in advanced glycation end products of serum proteins. The probiotic treatment adjusted the redox imbalance in the liver and kidney of diabetic rats, reduced the level of DNA damage, increased the activity of the pro-survival Akt kinase, decreased procaspase 3 degradation and lowered the level of inflammatory mediator C/EBPβ. Administration of probiotic to diabetic rats attenuated fibrotic process activated in the liver and kidneys as judged by the increase in E-cadherin and decreases in α-smooth muscle actin and fibronectin. In summary, the probiotic administration had an ameliorating effect on diabetes-associated disturbed redox homeostasis, inflammation and fibrosis, which underline the development of diabetic complications.
Ključne reči:
Diabetes; Antidiabetic effect; Fibrosis; Inflammation; Lactobacillus paraplantarum BGCG11 probiotic; Oxidative stressIzvor:
Journal of Functional Foods, 2017, 38, Part A, 427-437Finansiranje / projekti:
- Signalni molekuli u dijabetesu: identifikacija potencijalnih bioloških markera uključenih u modifikaciju i integraciju signalnih puteva u cilju predikcije i intervencije u dijabetesu (RS-MESTD-Basic Research (BR or ON)-173020)
DOI: 10.1016/j.jff.2017.09.033
ISSN: 1756-4646
WoS: 000414890500044
Scopus: 2-s2.0-85029725408
URI
http://linkinghub.elsevier.com/retrieve/pii/S1756464617305546https://radar.ibiss.bg.ac.rs/handle/123456789/2862