Приказ основних података о документу
The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats
dc.creator | Milošević, Marija D. | |
dc.creator | Paunović, Milica G. | |
dc.creator | Matić, Miloš M. | |
dc.creator | Ognjanović, Branka I. | |
dc.creator | Saičić, Zorica | |
dc.date.accessioned | 2017-11-23T11:33:43Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1382-6689 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S1382668917302740 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2863 | |
dc.description.abstract | Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5 mg/kg b.w.) and vitamin C (100 mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20 mg/kg b.w) for 30 days. Fenitrothion caused changes in body weight, food and water intake, and some haematological and biochemical parameters. Fenitrothion altered the glutathione redox status (GSH and GSSG) and decreased activity of antioxidant enzymes (GSH-Px, GST, SOD and CAT), leading to a lipid peroxidation. Selenium and vitamin C, by improving the activity of antioxidants, reduced oxidative stress and a lipid peroxidation, maintaining the values of examined parameters to optimal levels. Therefore, selenium and vitamin C could be useful in providing protection of exposed non-target organisms including people from fenitrothion. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173041/RS// | |
dc.rights | restrictedAccess | |
dc.source | Environmental Toxicology and Pharmacology | |
dc.subject | Fenitrothion | |
dc.subject | Selenium | |
dc.subject | Vitamin C | |
dc.subject | Oxidative stress | |
dc.subject | Antioxidative defence | |
dc.title | The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саичић, Зорица; Матић, Милош М.; Пауновић, Милица Г.; Милошевић, Марија Д.; Огњановић, Бранка И.; | |
dc.rights.holder | © 2017 Elsevier B.V. | |
dc.citation.volume | 56 | |
dc.identifier.doi | 10.1016/j.etap.2017.09.016 | |
dc.identifier.pmid | 28961515 | |
dc.identifier.scopus | 2-s2.0-85029856034 | |
dc.identifier.wos | 000418222300028 | |
dc.citation.apa | Milošević, M. D., Paunović, M. G., Matić, M. M., Ognjanović, B. I., & Saičić, Z. S. (2017). The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats. Environmental Toxicology and Pharmacology, 56, 204–209. | |
dc.citation.vancouver | Milošević MD, Paunović MG, Matić MM, Ognjanović BI, Saičić ZS. The ameliorating effects of selenium and vitamin C against fenitrothion-induced blood toxicity in Wistar rats. Environ Toxicol Pharmacol. 2017;56:204–9. | |
dc.citation.spage | 204 | |
dc.citation.epage | 209 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 |