Anti-encephalitogenic effects of ethyl pyruvate are reflected in the central nervous system and the gut.
2017
Аутори:
Nikolovski, NedaStanisavljević, Suzana
Jevtić, Bojan
Momčilović, Miljana
Lavrnja, Irena
Miljković, Đorđe
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2017 Elsevier Masson SAS
Метаподаци
Приказ свих података о документуАпстракт:
Ethyl pyruvate is a redox analogue of dimethyl fumarate (Tecfidera), a drug for multiple sclerosis treatment. We have recently shown that ethyl pyruvate ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. It affects encephalitogenic T cells and macrophages in vitro, as well as in lymph nodes draining the site of encephalitogenic immunization and within the central nervous system (CNS). Here, in vivo effects of ethyl pyruvate on EAE are thoroughly investigated in the CNS and within the gut associated lymphoid tissue. Ethyl pyruvate reduced infiltrates within the CNS and number of activated macrophages/microglia (ED1(+)/Iba1(+)) and proliferating astrocytes (GFAP(+)). Furthermore, it reduced expression of HMGB1 in activated macrophages/microglia. It also reduced number of activated T cells and antigen-presenting cells and expression of Th1/Th17-related molecules in mesenteric lymph nodes and Peyer's patches. These results contribute to our understanding of anti-encephalitogenic effects of ethyl pyruvate as they provide evidence of its effects within the CNS and imply that these effects are related to reduction of inflammatory immune response in gut associated lymphoid tissue.
Кључне речи:
Experimental autoimmune encephalomyelitis; Ethyl pyruvate; HMGB1; Gut associated lymphoid tissue; Multiple sclerosisФинансирање / пројекти:
- Ћелијски и молекулски механизми опоравка пацова од експерименталног аутоимунског енцефаломијелитиса (RS-MESTD-Basic Research (BR or ON)-173035)
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-MESTD-Basic Research (BR or ON)-173013)
- Ћелијска и молекулска основа неуроинфламације: потенцијала циљна места за транслациону медицину и терапију (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
У:
- Biomedicine & Pharmacotherapy (2017), 96: 78-85
DOI: 10.1016/j.biopha.2017.09.110
ISSN: 0753-3322
PubMed: 28965011
WoS: 000418502100011
Scopus: 2-s2.0-85030149033
URI
http://linkinghub.elsevier.com/retrieve/pii/S0753332217331694http://www.sciencedirect.com/science/article/pii/S0753332217331694
https://radar.ibiss.bg.ac.rs/handle/123456789/2864