Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation
2017
Authors:
Đorđević, MarijaArambašić Jovanović, Jelena
Tolić, Anja
Đorđević, Miloš
Mihailović, Mirjana
Grdović, Nevena
Uskoković, Aleksandra
Rajić, Jovana
Dinić, Svetlana
Jurkowski, Tomasz P.
Vidaković, Melita
Document Type:
Conference object (Published version)
Metadata
Show full item recordAbstract:
Since diabetes is characterized by impaired ability of pancreatic beta-cells to respond and/or produce insulin, new approaches for renewal and replacement of deficient beta-cells are indispensable. Generation of new insulin-producing cells from other cell types is a major aim of regenerative medicine. It has been shown that loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of alpha cells to functional insulin-producing cells. Previous experiments revealed dedifferentiation of pancreatic beta to alpha cells in response to ablation of DNA methyltransferase 1 (Dnmt1) in beta cells.
Note:
Poster session presented at: CoMBoS. 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia. (P51-MBE)
internal-pdf://CoMBoS poster 2017 Marija Sinadinovic.pdf
Source:
1st Congress of Molecular Biologists of Serbia, 2017Funding / projects:
- Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes (RS-MESTD-Basic Research (BR or ON)-173020)