Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation
2017
Autori:
Đorđević, MarijaArambašić Jovanović, Jelena
Tolić, Anja
Đorđević, Miloš
Mihailović, Mirjana
Grdović, Nevena
Uskoković, Aleksandra
Rajić, Jovana
Dinić, Svetlana
Jurkowski, Tomasz P.
Vidaković, Melita
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Since diabetes is characterized by impaired ability of pancreatic beta-cells to respond and/or produce insulin, new approaches for renewal and replacement of deficient beta-cells are indispensable. Generation of new insulin-producing cells from other cell types is a major aim of regenerative medicine. It has been shown that loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of alpha cells to functional insulin-producing cells. Previous experiments revealed dedifferentiation of pancreatic beta to alpha cells in response to ablation of DNA methyltransferase 1 (Dnmt1) in beta cells.
Napomena:
Poster session presented at: CoMBoS. 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia. (P51-MBE)
internal-pdf://CoMBoS poster 2017 Marija Sinadinovic.pdf
Izvor:
1st Congress of Molecular Biologists of Serbia, 2017Finansiranje / projekti:
- Signalni molekuli u dijabetesu: identifikacija potencijalnih bioloških markera uključenih u modifikaciju i integraciju signalnih puteva u cilju predikcije i intervencije u dijabetesu (RS-MESTD-Basic Research (BR or ON)-173020)
Povezane informacije:
- Druga verzija
https://radar.ibiss.bg.ac.rs/handle/123456789/2868