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Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation
dc.creator | Đorđević, Marija | |
dc.creator | Arambašić Jovanović, Jelena | |
dc.creator | Tolić, Anja | |
dc.creator | Đorđević, Miloš | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Grdović, Nevena | |
dc.creator | Uskoković, Aleksandra | |
dc.creator | Rajić, Jovana | |
dc.creator | Dinić, Svetlana | |
dc.creator | Jurkowski, Tomasz P. | |
dc.creator | Vidaković, Melita | |
dc.date.accessioned | 2017-11-22T11:19:30Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2865 | |
dc.description.abstract | Since diabetes is characterized by impaired ability of pancreatic beta-cells to respond and/or produce insulin, new approaches for renewal and replacement of deficient beta-cells are indispensable. Generation of new insulin-producing cells from other cell types is a major aim of regenerative medicine. It has been shown that loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of alpha cells to functional insulin-producing cells. Previous experiments revealed dedifferentiation of pancreatic beta to alpha cells in response to ablation of DNA methyltransferase 1 (Dnmt1) in beta cells. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | |
dc.relation.isversionof | https://radar.ibiss.bg.ac.rs/handle/123456789/2868 | |
dc.rights | restrictedAccess | |
dc.source | 1st Congress of Molecular Biologists of Serbia | |
dc.title | Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation | en |
dc.type | conferenceObject | |
dc.rights.license | ARR | |
dcterms.abstract | Рајић, Јована; Михаиловић, Мирјана; Видаковић, Мелита; Динић, Светлана; Јуркоwски, Томасз П.; Ускоковић, Aлександра; Ђорђевић, Милош; Грдовић, Невена; Синадиновић, Марија; Толић, Aња; Aрамбашић Јовановић, Јелена; | |
dc.description.note | Poster session presented at: CoMBoS. 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia. (P51-MBE) | |
dc.description.note | internal-pdf://CoMBoS poster 2017 Marija Sinadinovic.pdf | en |
dc.citation.apa | Sinadinović, M., Arambašić Jovanović, J., Tolić, A., Đorđević, M., Mihailović, M., Grdović, N., Uskoković, A., Rajić, J., Dinić, S., Jurkowski, T. & Vidaković, M. (2017). Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation. 1st Congress of Molecular Biologists of Serbia. | |
dc.citation.vancouver | Sinadinović M, Arambašić Jovanović J, Tolić A, Đorđević M, Mihailović M, Grdović N, Uskoković A, Rajić J, Dinić S, Jurkowski T, Vidaković M. Transdifferentiation of pancreatic alpha to beta cells using Epi-CRISPR directed DNA methylation. Poster session presented at: CoMBoS. 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia. | |
dc.type.version | publishedVersion | en |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_2865 |