Chlamydia trachomatis infection and development of epithelial mesenchymal transition in conjunctiva: possible epigenetic mechanisms unveiled
2017
Authors:
Rajić, JovanaGrdović, Nevena
Inic-Kanada, Aleksandra
Stein, Elisabeth
Schuerer, Nadine
Uskoković, Aleksandra
Ghasemian, Ehsan
Dinić, Svetlana
Mihailović, Mirjana
Arambašić Jovanović, Jelena
Tolić, Anja
Đorđević, Marija
Đorđević, Miloš
Poznanović, Goran
Barisani-Asenbauer, Talin
Vidaković, Melita
Document Type:
Conference object (Published version)
,
© Institute for Biological Research "Siniša Stanković"
Metadata
Show full item recordAbstract:
Trachoma is the leading infectious cause of blindness worldwide initiated by repeated infections of the conjunctiva with Chlamydia trachomatis (Ct). Consequent chronic inflammation results in formation of fibrotic tissue which can eventually lead to damage of the corneal surface. Lately, emerging evidence suggests involvement of epithelial to mesenchymaltransition (EMT) in development of every fibrotic process. Process of EMT represents reversible transition of epithelial into mesenchymalcells that can be traced through numerous markers such as E-cadherin, highly expressed in epithelial cells, α-SMA, a frequently used mesenchymalEMT marker and fibronectin, a glycoprotein whose expression increases during the EMT process. Recent findings have suggested that epigenetic events are master regulators of expression of many EMT related genes.
Note:
Poster session presented at: CoMBoS. 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia. (P48-MBE)
Funding / projects:
- Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes (RS-MESTD-Basic Research (BR or ON)-173020)
In:
- (poster) 1st Congress of Molecular Biologists of Serbia; 2017 Sep 20-22; Belgrade, Serbia.