Physiological regulation and metabolic role of browning in white adipose tissue
2017
Аутори:
Janković, AleksandraOtašević, Vesna
Stančić, Ana
Buzadžić, Biljana
Korać, Aleksandra
Korać, Bato
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2017 Walter de Gruyter GmbH, Berlin/Boston.
Метаподаци
Приказ свих података о документуАпстракт:
Great progress has been made in our understanding of the browning process in white adipose tissue (WAT) in rodents. The recognition that i) adult humans have physiologically inducible brown adipose tissue (BAT) that may facilitate resistance to obesity and ii) that adult human BAT molecularly and functionally resembles beige adipose tissue in rodents, reignited optimism that obesity and obesity-related diabetes type 2 can be battled by controlling the browning of WAT. In this review the main cellular mechanisms and molecular mediators of browning of WAT in different physiological states are summarized. The relevance of browning of WAT in metabolic health is considered primarily through a modulation of biological role of fat tissue in overall metabolic homeostasis.
Кључне речи:
Adipose tissue; Browning; Diabetes; Obesity; UCP1Извор:
Hormone Molecular Biology and Clinical Investigation, 2017, 31, 1, 20170034-20170034
DOI: 10.1515/hmbci-2017-0034
ISSN: 1868-1883
PubMed: 28862984
WoS: 000411905100007
Scopus: 2-s2.0-85030684483
URI
http://www.degruyter.com/view/j/hmbci.2017.31.issue-1/hmbci-2017-0034/hmbci-2017-0034.xmlhttps://radar.ibiss.bg.ac.rs/handle/123456789/2877