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Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats.
dc.creator | Kovačević, Sanja | |
dc.creator | Brkljačić, Jelena | |
dc.creator | Matić, Gordana | |
dc.creator | Elaković, Ivana | |
dc.date.accessioned | 2017-12-04T14:24:40Z | |
dc.date.available | 2017-12-04T14:24:40Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1436-6207 | |
dc.identifier.uri | http://link.springer.com/10.1007/s00394-015-1065-0 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/26433940 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2917 | |
dc.description.abstract | PURPOSE The consumption of refined, fructose-enriched food continuously increases and has been linked to development of obesity, especially in young population. Low-grade inflammation and increased oxidative stress have been implicated in the pathogenesis of obesity-related disorders including type 2 diabetes. In this study, we examined alterations in inflammation and antioxidative defense system in the visceral adipose tissue (VAT) of fructose-fed young female rats, and related them to changes in adiposity and insulin sensitivity. METHODS We examined the effects of 9-week fructose-enriched diet applied immediately after weaning on nuclear factor κB (NF-κB) intracellular distribution, and on the expression of pro-inflammatory cytokines (IL-1β and TNFα) and key antioxidative enzymes in the VAT of female rats. Insulin signaling in the VAT was evaluated at the level of insulin receptor substrate-1 (IRS-1) protein and its inhibitory phosphorylation on Ser307. RESULTS Fructose-fed rats had increased VAT mass along with increased NF-κB nuclear accumulation and elevated IL-1β, but not TNFα expression. The protein levels of antioxidative defense enzymes, mitochondrial manganese superoxide dismutase 2, and glutathione peroxidase, were reduced, while the protein content of IRS-1 and its inhibitory phosphorylation were not altered by fructose diet. CONCLUSIONS The results suggest that fructose overconsumption-related alterations in pro-inflammatory markers and antioxidative capacity in the VAT of young female rats can be implicated in the development of adiposity, but do not affect inhibitory phosphorylation of IRS-1. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | |
dc.rights | restrictedAccess | |
dc.source | European journal of nutrition | |
dc.source | European Journal of Nutrition | |
dc.subject | Female rats | |
dc.subject | Fructose diet | |
dc.subject | Inflammation | |
dc.subject | NF-κB | |
dc.subject | Oxidative stress | |
dc.subject | Visceral adipose tissue | |
dc.title | Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Матић, Гордана; Ковачевић, Сања; Несторов, Јелена; Елаковић, Ивана; | |
dc.rights.holder | © 2015, Springer-Verlag Berlin Heidelberg. | |
dc.citation.issue | 1 | |
dc.citation.volume | 56 | |
dc.identifier.doi | 10.1007/s00394-015-1065-0 | |
dc.identifier.pmid | 26433940 | |
dc.identifier.scopus | 2-s2.0-84944566005 | |
dc.identifier.wos | 000394168100013 | |
dc.citation.apa | Kovačević, S., Nestorov, J., Matić, G., & Elaković, I. (2017). Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats. European journal of nutrition, 56(1), 151–160. | |
dc.citation.vancouver | Kovačević S, Nestorov J, Matić G, Elaković I. Fructose-enriched diet induces inflammation and reduces antioxidative defense in visceral adipose tissue of young female rats. Eur J Nutr. 2017;56(1):151–60. | |
dc.citation.spage | 151 | |
dc.citation.epage | 160 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |