New N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents
2017
Аутори:
Incerti, MatteoVicini, Paola
Geronikaki, Athina
Eleftheriou, Phaedra
Tsagkadouras, Athanasios
Zoumpoulakis, Panagiotis
Fotakis, Charalmpos
Ćirić, Ana
Glamočlija, Jasmina
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© The Royal Society of Chemistry 2017
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A series of 21 novel N-[2-phenyl-4-oxo-1,3-thiazolidin-3-yl]-1,2-benzothiazole-3-carboxamides/acetamides (4a–4p) as well as a series of N′-(halophenylmethylidene)-1,2-benzothiazole-3-acetohydrazides (3h–3p) have been synthesized and evaluated for their antimicrobial activity against eight bacterial and eight fungal species, among them plant, animal and human pathogens and food contaminating species. All compounds appeared to be potent and the best activity was exhibited by compound 4d with MIC in the range of 10.7–21.4 μmol mL−1 × 10−2 and MBC of 21.4–40.2 μmol mL−1 × 10−2. The best antifungal activity was observed for compounds 4p and 3h. Elucidation of the relationship between the antimicrobial activity and molecular properties of the synthesized compounds was also performed. Synthetic intermediates were also tested with several exhibiting good antimicrobial activities. Docking studies for some compounds were performed.
Извор:
MedChemComm, 2017, 8, 11, 2142-2154
DOI: 10.1039/C7MD00334J
ISSN: 2040-2503
PubMed: 30108732