Sleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat
2018
Autori:
Ćirić, JelenaLazić, Katarina
Kapor, Slobodan
Perović, Milka
Petrović, Jelena
Pešić, Vesna
Kanazir, Selma
Šaponjić, Jasna
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2017 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the basal and stimulated locomotor activity. Sleep and basal locomotor activity in adult Wistar rats were followed during their inactive circadian phase, and throughout the same aging period. The bilateral PPT lesions were done by 0.1M ibotenic acid (IBO) during the surgical procedure for implantation of the electroencephalographic (EEG) and electromyographic (EMG) electrodes for chronic sleep recording. The cholinergic neuronal loss was identified by NADPH - diaphorase histochemistry. After all sleep and behavioral recording sessions, the locomotor activity was stimulated by d-amphetamine (d-AMPH) and the neuronal activity of striatum was followed by c-Fos immunolabeling. Impaired cholinergic innervation from the PPT was expressed earlier as sleep disorder then as movement disorder, and it was the earliest and long-lasting at hippocampal and thalamo-cortical level, and followed by a delayed "hypokinesia". This severe impact of a tonically impaired PPT cholinergic innervation was evidenced as the cholinergic interneuronal loss of the caudate putamen and as a suppressed c-Fos expression after stimulation by d-AMPH. In order how they occurred, the hippocampal non rapid eye movement (NREM) sleep disorder, altered high voltage sleep spindle (HVS) dynamics during rapid eye movement (REM) sleep in the hippocampus and motor cortex, and "hypokinesia" may serve as the biomarkers of PD cholinopathy onset and progression.
Ključne reči:
High voltage sleep spindles; Locomotor activity; Parkinson’s disease; Pedunculopontine tegmental nucleus; Sleep; c-FosIzvor:
Behavioural Brain Research, 2018, 339, 79-92Finansiranje / projekti:
- Neurobiologija spavanja u starenju i bolesti - elektroencefalografski markeri i modeliranje u proceni poremećaja (RS-MESTD-Basic Research (BR or ON)-173022)
- Plastičnost mozga tokom starenja: uticaj dijetalne restrikcije i anestezije (RS-MESTD-Basic Research (BR or ON)-173056)
Povezane informacije:
- Druga verzija
https://radar.ibiss.bg.ac.rs/handle/123456789/3361
DOI: 10.1016/j.bbr.2017.11.021
ISSN: 0166-4328
PubMed: 29170000
WoS: 000424173300010
Scopus: 2-s2.0-85034764500
URI
http://linkinghub.elsevier.com/retrieve/pii/S0166432817312391http://www.ncbi.nlm.nih.gov/pubmed/29170000
https://radar.ibiss.bg.ac.rs/handle/123456789/2932