dc.creator | Edeler, David | |
dc.creator | Arlt, Sören | |
dc.creator | Petković, Vladana | |
dc.creator | Ludwig, Gerd | |
dc.creator | Drača, Dijana | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2018-01-11T09:40:13Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S0162013417306165 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/29288894 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2954 | |
dc.description.abstract | SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential. According to the loaded amount of the [Ru] in SBA-15|[Ru] and SBA-15~SH|[Ru] the IC50 values are 1-2μM depending on the test used, thus in comparison to [Ru] alone the activity of nanomaterials containing [Ru] are elevated 3-6 times in vitro. However, the mechanism of apoptosis induction differs for these two mesoporous silica. Unlike reference [Ru] compound and SBA-15~SH|[Ru], SBA-15|[Ru] induces high caspase activation. Discrepancy in mechanism of drugs action at intracellular level points towards an influence of functionalization as well as availability of the drug. Moreover, both SBA-15|[Ru] and SBA-15~SH|[Ru] similarly to [Ru] are declining autophagy in B16 cell line. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Inorganic Biochemistry | |
dc.subject | Apoptosis | |
dc.subject | Autophagy | |
dc.subject | Cytotoxicity | |
dc.subject | Drug delivery | |
dc.subject | Ruthenium(II) complex | |
dc.subject | SBA-15 | |
dc.title | Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Максимовић-Иванић, Данијела; Петковић, Владана; Aрлт, Сöрен; Еделер, Давид; Лудwиг, Герд; Драча, Дијана; Калуђеровић, Горан Н.; Мијатовић, Сања; | |
dc.rights.holder | © 2017 Elsevier Inc. | |
dc.citation.volume | 180 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2017.12.011 | |
dc.identifier.pmid | 29288894 | |
dc.identifier.scopus | 2-s2.0-85039450859 | |
dc.identifier.wos | 000426621000017 | |
dc.citation.apa | Edeler, D., Arlt, S., Petković, V., Ludwig, G., Drača, D., Maksimović-Ivanić, D., Mijatović, S., et al. (2018). Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study. Journal of Inorganic Biochemistry, 180, 155–162. | |
dc.citation.vancouver | Edeler D, Arlt S, Petković V, Ludwig G, Drača D, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized and mercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study. J Inorg Biochem. 2018;180:155–62. | |
dc.citation.spage | 155 | |
dc.citation.epage | 162 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |