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Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models.
dc.creator | Kolarević, Stoimir | |
dc.creator | Milovanović, Dragana | |
dc.creator | Kračun-Kolarević, Margareta | |
dc.creator | Kostić, Jovana | |
dc.creator | Sunjog, Karolina | |
dc.creator | Martinović, Rajko | |
dc.creator | Đorđević, Jelena | |
dc.creator | Novaković, Irena | |
dc.creator | Sladić, Dušan | |
dc.creator | Vuković-Gačić, Branka | |
dc.date.accessioned | 2018-02-08T10:46:42Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0148-0545 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/01480545.2017.1413108 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2966 | |
dc.description.abstract | In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3'-methoxyavarone, 4'-(methylamino)avarone and 3'-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3'-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3'-methoxyavarone and 3'-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.rights | restrictedAccess | |
dc.source | Drug and Chemical Toxicology | |
dc.subject | Avarol | |
dc.subject | SOS/umuC | |
dc.subject | Avarone | |
dc.subject | Comet assay | |
dc.subject | Genotoxicity | |
dc.subject | Mutagenicity | |
dc.title | Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Миловановић, Драгана; Коларевић, Стоимир; Крачун-Коларевић, Маргарета; Костић, Јована; Суњог, Каролина; Ђорђевић, Јелена; Вуковић-Гачић, Бранка; Сладић, Душан; Новаковић, Ирена; Мартиновић, Рајко; | |
dc.rights.holder | © 2017 Informa UK Limited, trading as Taylor & Francis Group | |
dc.citation.issue | 2 | |
dc.citation.volume | 42 | |
dc.identifier.doi | 10.1080/01480545.2017.1413108 | |
dc.identifier.pmid | 29299944 | |
dc.identifier.scopus | 2-s2.0-85041102861 | |
dc.identifier.wos | 000459818600003 | |
dc.citation.apa | Kolarević, S., Milovanović, D., Kračun-Kolarević, M., Kostić, J., Sunjog, K., Martinović, R., Đorđević, J., et al. (2018). Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models. Drug and Chemical Toxicology, 42 (2) 130-139. | |
dc.citation.vancouver | Kolarević S, Milovanović D, Kračun-Kolarević M, Kostić J, Sunjog K, Martinović R, Đorđević J, Novaković I, Sladić D, Vuković-Gačić B. Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models. Drug Chem Toxicol. 2018;42(2):130-9. | |
dc.citation.spage | 130 | |
dc.citation.epage | 139 | |
dc.type.version | publishedVersion | |
dc.citation.rank | M22 |
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