Age-related changes in antioxidant and glutathione S-transferase enzyme activities in the Asian clam
2016
Document Type:
Article (Published version)
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© Pleiades Publishing, Ltd., 2016.
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Show full item recordAbstract:
Aging is accompanied by increased production of free oxygen radicals and impairment of normal cellular functions. The aim of this work was to provide preliminary data on age-related differences in the activities of antioxidant enzymes and phase II biotransformation enzyme glutathione S-transferase (GST) in a wild population of the Asian clam Corbicula fluminea. The antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), and GST were assessed in visceral mass of four age classes (0+-, 1+-, 2+-, and 3+-year-old) of C. fluminea clams. Age-related changes were seen in antioxidant enzyme status: levels of total SOD (totSOD) (P < 0.05), MnSOD, and CuZnSOD (P < 0.05) activities increased progressively during aging from younger to older clams. Changes in CAT and GR activities with advancing age were found, the levels being the highest in age class II, then being lower in age classes III and IV (P < 0.05). Activities of GPX and GST were lower in the senescent individuals (2+- and 3+-year-old clams) compared with young individuals (0+- and 1+-year-old clams). Overall, the decline of glutathione-dependent enzyme activities, coupled with higher and lower activities of totSOD and CAT, respectively, as the individual grows older, may render the older animals more susceptible to oxidative stress. Data reported here are not intended to be exhaustive since they concern only age/size structure of the population at one locality, so more detailed studies on both the developmental stages and levels of antioxidant enzymes of this new alien species in Serbian rivers are required.
Keywords:
Asian clam; GST; Aging; antioxidant enzymeSource:
Biochemistry (Moscow), 2016, 81, 3, 224-232Funding / projects:
- Evolution in Heterogeneous Environments: Adaptation Mechanisms, Biomonitoring and Conservation of Biodiversity (RS-MESTD-Basic Research (BR or ON)-173025)
DOI: 10.1134/S0006297916030044
ISSN: 0006-2979
PubMed: 27262191
WoS: 000373346300004
Scopus: 2-s2.0-84964026858
URI
https://link.springer.com/article/10.1134%2FS0006297916030044#copyrightInformationhttps://radar.ibiss.bg.ac.rs/handle/123456789/2981