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Chemical Composition and Bioactivity of the Essential Oils of Heracleum pyrenaicum subsp. pollinianum and Heracleum orphanidis.
dc.creator | Usjak, Ljubos | |
dc.creator | Petrović, Silvana | |
dc.creator | Drobac, Milica | |
dc.creator | Soković, Marina | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Ćirić, Ana | |
dc.creator | Niketić, Marjan | |
dc.date.accessioned | 2018-02-14T10:16:00Z | |
dc.date.available | 2018-02-14T10:16:00Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/27396211 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2990 | |
dc.description.abstract | The objective of this research was to analyze the chemical composition, antimicrobial and cytotoxic activity of Heracleun pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti (HPP) and H. orphanidis Boiss. (HO) essential oils. The composition of the oils was analyzed by GC and GC-MS. β-Pinene (35.1%) was the most abundant compound in HPP root oil, while (Z)-falcarinol (80.0%) dominated in HO root oil. (E)-Nerolidol (28.5%) was the main constituent in HPP leaf oil. HPP fruit oil, as well as HO leaf and fruit oils mainly contained aliphatic esters, mostly octyl acetate (50.5-84.5%). Antimicrobial screening was performed by microdilution method against eight bacterial and eight fungal strains. The strongest antibacterial activity was shown by both root oils (MICs 0.02-0.60 mg/mL and MBCs 0.04-2.50 mg/mL for HPP, and MICs 0.02-1.25 mg/mL and MBCs 0.04-2.50 mg/mL for HO), while the best antifungal potential was exhibited by HPP fruit oil (MICs 0.30-0.60 mg/mL and MFCs 0.60-1.25 mg/mL) and HO leaf oil (MICs 0.15-0.63 mg/mL and MFCs 0.30-1.25 mg/mL). The tested root and fruit oils exhibited strong cytotoxic effect, which was determined by MTT test against HeLa (IC50 7.53-21.07 µg/mL) and LS174 (IC50 24.16-58.86 µg/mL) cell lines. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Communications | |
dc.title | Chemical Composition and Bioactivity of the Essential Oils of Heracleum pyrenaicum subsp. pollinianum and Heracleum orphanidis. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Никетић, Марјан; Станојковић, Татјана; Соковић, Марина; Дробац, Милица; Петровић, Силвана; Усјак, Љубос; Ћирић, Aна; | |
dc.rights.holder | © Natural Product Incorporation | |
dc.citation.issue | 4 | |
dc.citation.volume | 11 | |
dc.identifier.pmid | 27396211 | |
dc.identifier.scopus | 2-s2.0-84989193394 | |
dc.identifier.wos | 000375633400028 | |
dc.citation.spage | 529 | |
dc.citation.epage | 34 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_2990 |
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