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Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.

dc.creatorKrstić, Gordana
dc.creatorJadranin, Milka
dc.creatorTodorović, Nina M.
dc.creatorPešić, Milica
dc.creatorStanković, Tijana
dc.creatorAljančić, Ivana S.
dc.creatorTešević, Vele V.
dc.date.accessioned2018-02-23T08:53:48Z
dc.date.available2900-01-01
dc.date.issued2018
dc.identifier.issn0031-9422
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0031942218300232?via%3Dihub
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/3003
dc.description.abstractSeven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.en
dc.publisherPergamon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectDiterpenoids
dc.subjectEuphorbia nicaeensis
dc.subjectEuphorbiaceae
dc.subjectIsolation
dc.subjectJatrophanes
dc.subjectMulti-drug resistance
dc.subjectP-glycoprotein
dc.subjectStructutre determination
dc.titleJatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis.en
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractAљанчић, Ивана С.; Станковић, Тијана; Пешић, Милица; Крстић, Гордана; Тодоровић, Нина М.; Тешевић, Веле В.; Јадранин, Милка;
dc.rights.holder© 2018 Elsevier Ltd
dc.citation.volume148
dc.identifier.doi10.1016/j.phytochem.2018.01.016
dc.identifier.pmid29421506
dc.identifier.scopus2-s2.0-85041594265
dc.identifier.wos000427334600013
dc.citation.apaKrstić, G., Jadranin, M., Todorović, N. M., Pešić, M., Stanković, T., Aljančić, I. S., & Tešević, V. V. (2018). Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. Phytochemistry, 148, 104–112.
dc.citation.vancouverKrstić G, Jadranin M, Todorović NM, Pešić M, Stanković T, Aljančić IS, Tešević V V. Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. Phytochemistry. 2018;148:104–12.
dc.citation.spage104
dc.citation.epage112
dc.type.versionpublishedVersionen
dc.citation.rankM21


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