Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis.
2018
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2018 Wiley Periodicals, Inc.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system (CNS) that affects more than two million people worldwide. Several animal models resemble MS pathology; the most employed are experimental autoimmune encephalomyelitis (EAE) and toxin- and/or virus-induced demyelination. In this review we will summarize our knowledge on the utility of different animal models in MS research. Although animal models cannot replicate the complexity and heterogeneity of the MS pathology, they have proved to be useful for the development of several drugs approved for treatment of MS patients. This review focuses on EAE because it represents both clinical and pathological features of MS. During the past decades, EAE has been effective in illuminating various pathological processes that occur during MS, including inflammation, CNS penetration, demyelination, axonopathy, and neuron loss mediated by immune cells.
Ključne reči:
EAE; Ethidium bromide; Glial cells; Lysolecithin toxin and virus-induced demyelination; Multiple sclerosisIzvor:
Journal of Neuroscience Research, 2018, 96, 6, 1021-1042Finansiranje / projekti:
- Ćelijska i molekulska osnova neuroinflamacije: potencijala ciljna mesta za translacionu medicinu i terapiju (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
DOI: 10.1002/jnr.24224
ISSN: 0360-4012
PubMed: 29446144