Приказ основних података о документу
Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis.
dc.creator | Bjelobaba, Ivana | |
dc.creator | Begović-Kuprešanin, Vesna | |
dc.creator | Peković, Sanja | |
dc.creator | Lavrnja, Irena | |
dc.date | 2019-02-15 | |
dc.date.accessioned | 2018-03-09T10:31:50Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0360-4012 | |
dc.identifier.uri | http://doi.wiley.com/10.1002/jnr.24224 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3010 | |
dc.description.abstract | Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system (CNS) that affects more than two million people worldwide. Several animal models resemble MS pathology; the most employed are experimental autoimmune encephalomyelitis (EAE) and toxin- and/or virus-induced demyelination. In this review we will summarize our knowledge on the utility of different animal models in MS research. Although animal models cannot replicate the complexity and heterogeneity of the MS pathology, they have proved to be useful for the development of several drugs approved for treatment of MS patients. This review focuses on EAE because it represents both clinical and pathological features of MS. During the past decades, EAE has been effective in illuminating various pathological processes that occur during MS, including inflammation, CNS penetration, demyelination, axonopathy, and neuron loss mediated by immune cells. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroscience Research | |
dc.subject | EAE | |
dc.subject | Ethidium bromide | |
dc.subject | Glial cells | |
dc.subject | Lysolecithin toxin and virus-induced demyelination | |
dc.subject | Multiple sclerosis | |
dc.title | Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Пековић, Сања; Беговић-Купрешанин, Весна; Лаврња, Ирена; Бјелобаба, Ивана; | |
dc.rights.holder | © 2018 Wiley Periodicals, Inc. | |
dc.citation.issue | 6 | |
dc.citation.volume | 96 | |
dc.identifier.doi | 10.1002/jnr.24224 | |
dc.identifier.pmid | 29446144 | |
dc.identifier.scopus | 2-s2.0-85042092581 | |
dc.identifier.wos | 000430111400008 | |
dc.citation.apa | Bjelobaba, I., Begovic-Kupresanin, V., Pekovic, S., & Lavrnja, I. (2018). Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis. Journal of Neuroscience Research, 96 (6) 1021-1042. | |
dc.citation.vancouver | Bjelobaba I, Begovic-Kupresanin V, Pekovic S, Lavrnja I. Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis. J Neurosci Res. 2018;96(6):1021-42. | |
dc.citation.spage | 1021 | |
dc.citation.epage | 1042 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |