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Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients.
dc.creator | Paunović, Verica | |
dc.creator | Vukovič Petrović, Irena | |
dc.creator | Milenković, Marina | |
dc.creator | Janjetović, Kristina | |
dc.creator | Pravica, Vera | |
dc.creator | Dujmović, Irena | |
dc.creator | Milošević, Emina | |
dc.creator | Martinović, Vanja | |
dc.creator | Mesaroš, Šarlota | |
dc.creator | Drulović, Jelena | |
dc.creator | Trajković, Vladimir | |
dc.date | 2019-03-05 | |
dc.date.accessioned | 2018-03-22T09:57:21Z | |
dc.date.available | 2018-03-22T09:57:21Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | http://www.jni-journal.com/article/S0165-5728(17)30538-6/abstract | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3014 | |
dc.description.abstract | Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4+and CD4-T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4+T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175038/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | |
dc.subject | ATG5 | |
dc.subject | Autophagy | |
dc.subject | LC3 | |
dc.subject | Multiple sclerosis | |
dc.subject | SQSTM1 | |
dc.subject | T cells | |
dc.subject | TNF | |
dc.title | Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Мартиновић, Вања; Месарош, Шарлота; Друловић, Јелена; Трајковић, Владимир; Правица, Вера; Пауновић, Верица; Вукович Петровић, Ирена; Миленковић, Марина; Јањетовић, Кристина; Дујмовић, Ирена; Милошевић, Емина; | |
dc.rights.holder | © 2018 Elsevier B.V. | |
dc.citation.volume | 319 | |
dc.identifier.doi | 10.1016/j.jneuroim.2018.03.001 | |
dc.identifier.pmid | 29548704 | |
dc.identifier.scopus | 2-s2.0-85043451518 | |
dc.identifier.wos | 000433016400014 | |
dc.citation.apa | Paunovic, V., Vukovic Petrovic, I., Milenkovic, M., Janjetovic, K., Pravica, V., Dujmovic, I., Milosevic, E., et al. (2018). Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients. Journal of Neuroimmunology, 319, 100-105. | |
dc.citation.vancouver | Paunovic V, Vukovic Petrovic I, Milenkovic M, Janjetovic K, Pravica V, Dujmovic I, Milosevic E, Martinovic V, Mesaros S, Drulovic J, Trajkovic V. Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients. J Neuroimmunol. 2018;319:100-5. | |
dc.citation.spage | 100 | |
dc.citation.epage | 105 | |
dc.type.version | publishedVersion | |
dc.citation.rank | M22 |
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