Prikaz osnovnih podataka o dokumentu
Can Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis?
dc.creator | Opačić, Miloš | |
dc.creator | Stević, Zorica | |
dc.creator | Baščarević, Vladimir | |
dc.creator | Živić, Miroslav | |
dc.creator | Spasić, Mihajlo | |
dc.creator | Spasojević, Ivan | |
dc.date.accessioned | 2018-05-28T11:38:08Z | |
dc.date.available | 2018-05-28T11:38:08Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://www.liebertpub.com/doi/10.1089/ars.2017.7433 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3065 | |
dc.description.abstract | The monitoring of progression in amyotrophic lateral sclerosis (ALS) relies on clinical outcome measures that take months to interpret, such as revised ALS functional rating scale (ALSFRS-R) score, with no approved biomarkers. A number of clinical studies have documented the involvement of oxidative stress in ALS pathology. Pertinent to this, we propose to evaluate oxidation-reduction potential (ORP) of cerebrospinal fluid (CSF) as a potential indicator of ALS progression. The case-control study included 24 patients with neurological non-neurodegenerative disorders (controls) and 82 ALS patients with different degrees of disease (ALSFRS-R score: 21-47). ORP was significantly higher in ALS patients than controls. It was not dependent on age or gender. A strong negative correlation was found between ORP and ALSFRS-R score for all patients and patients with spinal onset. In other words, ORP increased with ALS progression. No correlation was found for the subset of patients with bulbar onset, most likely because of the physical distance between neurodegenerative loci and the site of CSF collection. These results lead to the hypothesis that ORP of CSF has a potential as monitoring biomarker in ALS, particularly in the cohort of patients with spinal onset. Antioxid. Redox Signal. 28, 1570-1575. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | |
dc.rights | restrictedAccess | |
dc.source | Antioxidants and Redox Signaling | |
dc.subject | Amyotrophic lateral sclerosis | |
dc.subject | Biomarker | |
dc.subject | Cerebrospinal fluid | |
dc.subject | Oxidative stress | |
dc.subject | Progression | |
dc.title | Can Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis? | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Живић, Мирослав; Спасић, Михајло; Башчаревић, Владимир; Спасојевић, Иван; Опачић, Милош; Стевић, Зорица; | |
dc.rights.holder | © 2018, Mary Ann Liebert, Inc. 2018. | |
dc.citation.issue | 17 | |
dc.citation.volume | 28 | |
dc.identifier.doi | 10.1089/ars.2017.7433 | |
dc.identifier.pmid | 29113448 | |
dc.identifier.scopus | 2-s2.0-85046633968 | |
dc.identifier.wos | 000417814300001 | |
dc.citation.apa | Opačić, M., Stević, Z., Baščarević, V., Živić, M., Spasić, M., & Spasojević, I. (2018). Can Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis? Antioxidants and Redox Signaling, 28(17), 1570–1575. | |
dc.citation.vancouver | Opačić M, Stević Z, Baščarević V, Živić M, Spasić M, Spasojević I. Can Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis? Antioxidants Redox Signal. 2018;28(17):1570–5. | |
dc.citation.spage | 1570 | |
dc.citation.epage | 1575 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |
Dokumenti
Datoteke | Veličina | Format | Pregled |
---|---|---|---|
Uz ovaj zapis nema datoteka. |