Summer savory (Satureja hortensis L.) extract: Phytochemical profile and modulation of cisplatin-induced liver, renal and testicular toxicity.
2018
Аутори:
Boroja, TatjanaKatanić, Jelena
Rosić, Gvozden
Selaković, Dragica
Joksimović, Jovana
Mišić, Danijela
Stanković, Vesna
Jovičić, Nemanja
Mihailović, Vladimir
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2018 Elsevier Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
The aim of our study was to examine the potential ameliorating effect of the methanolic extract of Satureja hortensis L. (summer savory) aerial parts against cisplatin-induced oxidative damage in renal, hepatic, and testicular tissues. S. hortensis methanol extract at the doses of 50, 100 and 200 mg/kg of body weight were orally administered to Wistar rats once daily for 10 days. Toxicity was induced by intraperitoneal injection of a single dose of cisplatin (7.5 mg/kg of body weight) on the 5th day of the experiment. Applied treatment with S. hortensis extract restored tissue morphology, ameliorated levels of serum parameters for liver, renal and testes function, tissue oxidative stress parameters, and increased Bcl-2/Bax ratio as an indicator of apoptosis in experimental animals caused by application of cisplatin. UHPLC/DAD/HESI-MS/MS analysis revealed that S. hortensis extract was rich in phenolic compounds with rosmarinic acid (24.9 mg/g) as the main compound, followed by caffeic acid (1.28 mg/g) and naringenin (1.06 mg/g). Our findings suggest that S. hortensis may be a valuable source of dietary and pharmacologically important phenolic compounds, especially rosmarinic acid, in pharmaceutical and functional food formulations in order to maintain normal health conditions or as a remedy in various diseases caused by oxidative damage.
Кључне речи:
Cisplatin toxicity; Oxidative stress; Rosmarinic acid; Satureja hortensis L.Извор:
Food and Chemical Toxicology, 2018, 118, 252-263Финансирање / пројекти:
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Физиолошка, хемијска и молекуларна анализа диверзитета одабраних ретких и угрожених биљних врста у циљу еx ситу заштите и продукције биолошки активних једињења (RS-MESTD-Basic Research (BR or ON)-173024)
DOI: 10.1016/j.fct.2018.05.001
PubMed: 29746935
WoS: 000442714300025
Scopus: 2-s2.0-85046857232
URI
https://www.sciencedirect.com/science/article/pii/S0278691518302904?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3066