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Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15.
dc.creator | Krajnović, Tamara | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Drača, Dijana | |
dc.creator | Wolf, Katharina | |
dc.creator | Edeler, David | |
dc.creator | Wessjohann, Ludger A | |
dc.creator | Kaluđerović, Goran N | |
dc.date.accessioned | 2018-06-07T08:17:27Z | |
dc.date.available | 2018-06-07T08:17:27Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://www.mdpi.com/2079-4991/8/5/322 | |
dc.identifier.uri | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5977336 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3078 | |
dc.description.abstract | In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionally, SBA-15 loaded with EO (SBA-15|EO3) does not disturb viability of peritoneal macrophages. SBA-15|EO3 causes inhibition of tumor cell proliferation and triggers apoptosis, connected with caspase activation, upregulation of Bax, as well as Bcl-2 and Bim downregulation along with amplification of poly-(ADP-ribose)-polymerase (PARP) cleavage fragment. Thus, the mesoporous SBA-15 is a promising carrier of the water-insoluble drug emodin. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Nanomaterials (Basel, Switzerland) | |
dc.subject | SBA-15 | |
dc.subject | Apoptosis | |
dc.subject | Autophagy | |
dc.subject | Emodin | |
dc.subject | Melanoma | |
dc.title | Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15. | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Wессјоханн, Лудгер A; Крајновић, Тамара; Максимовић-Иванић, Данијела; Мијатовић, Сања; Драча, Дијана; Еделер, Давид; Wолф, Катхарина; Калуђеровић, Горан Н; | |
dc.rights.holder | © 2018 by the authors. Licensee MDPI, Basel, Switzerland | |
dc.citation.issue | 5 | |
dc.citation.volume | 8 | |
dc.identifier.doi | 10.3390/nano8050322 | |
dc.identifier.pmid | 29757198 | |
dc.identifier.scopus | 2-s2.0-85047644167 | |
dc.identifier.wos | 000435198300053 | |
dc.citation.vancouver | Krajnović T, Maksimović-Ivanić D, Mijatović S, Drača D, Wolf K, Edeler D, Wessjohann LA, Kaluđerović GN. Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15. Nanomater (Basel, Switzerland). 2018;8(5):322. | |
dc.citation.spage | 322 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/4320/Nanomater_2018_8_5_322.pdf | |
dc.citation.rank | M21 |