Nandrolone decanoate and physical activity affect quadriceps in peripubertal rats.
2018
Аутори:
Sretenović, JasminaAjdžanović, Vladimir
Živković, Vladimir
Srejović, Ivan
Čorbić, Milena
Milošević, Verica
Jakovljević, Vladimir
Milosavljević, Zoran
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2018 Elsevier GmbH
Метаподаци
Приказ свих података о документуАпстракт:
Anabolic androgenic steroids (AASs) are synthetic analogs of testosterone often used by athletes to increase the skeletal muscle mass. Our goal was to examine the effects of physical activity and physical activity combined with supraphysiological doses of nandrolone on functional morphology of the quadriceps muscle. The study included 32 peripubertal Wistar rats, divided into 4 groups: control (T-N-), nandrolone (T-N+), physical activity (T+N-) and physical activity plus nandrolone (T+N+) groups. The T+N- and T+N+ group swam for 4 weeks, 1 h/day, 5 days/week. The T-N+ and T+N+ groups received nandolone decanoate (20 mg/kg b.w.) once per week, subcutaneously. Subsequently, the rats were sacrificed and muscle specimens were prepared for the processing. Tissue sections were histochemically and immunohistochemically stained, while the image analysis was used for quantification. Longitudinal diameter of quadriceps muscle cells was increased for 21% in T-N+, for 57% in T+N- and for 64% in T+N+ group while cross section muscle cell area was increased in T-N+ for 19%, in T+N- for 47% and in T+N+ group for 59%, compared to the control. Collagen fibers covered area was increased in T-N+ group for 36%, in T+N- for 109% and in T+N+ group for 159%, compared to the control. Erythrocyte depots were decreased in T-N+ group and increased in T+N- and T+N+ group, in comparison with T-N-. VEGF depots were increased in all treated groups. Chronic administration of supraphysiological doses of AASs alone or in combination with physical activity induces hypertrophy and significant changes in the quadriceps muscle tissue structure.
Кључне речи:
Histomorphometry; Nandrolone; Physical activity; Quadriceps; RatИзвор:
Acta Histochemica, 2018, 120, 5, 429-437Финансирање / пројекти:
- Ефекти хомоцистеина и хомоцистеину сродних супстанци на кардиоваскуларни систем: Улога гасних трансмитера No, H2S и CO (RS-MESTD-Basic Research (BR or ON)-175043)
- Одговор неуроендокриног система пацова на одабране биљне екстракте, фитоестрогене, стероидне и пептидне хормоне (RS-MESTD-Basic Research (BR or ON)-173009)
DOI: 10.1016/j.acthis.2018.04.004
PubMed: 29759662
WoS: 000439253400005
Scopus: 2-s2.0-85046844631
URI
https://www.sciencedirect.com/science/article/pii/S0065128118300382?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3085