Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.
2018
Аутори:
Garcia, CatarinaSilva, Catarina Oliveira
Monteiro, Carlos M
Nicolai, Marisa
Viana, Ana
Andrade, Joana M
Barasoain, Isabel
Stanković, Tijana
Quintana, José
Hernández, Inmaculada
González, Ignacio
Estévez, Francisco
Díaz-Lanza, Ana M
Reis, Catarina P
Afonso, Carlos AM
Pešić, Milica
Rijo, Patrícia
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2018 Newlands Press
Метаподаци
Приказ свих података о документуАпстракт:
AIM 6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. METHODS/RESULTS Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. CONCLUSION DHR seems to be a promising starting material with anticancer properties to further be explored.
Кључне речи:
6,7-dehydroroyleanone; Plectranthus; cytotoxicity; extraction; isolation; multidrug resistance; nanotechnologyИзвор:
Future Medicinal Chemistry, 2018, 10, 10, 1177-1189Финансирање / пројекти:
- Идентификација молекуларних маркера за предикцију прогресије тумора, одговора на терапију и исхода болести (RS-41031)
- Fundação para a Ciência e a Tecnologia
DOI: 10.4155/fmc-2017-0239
PubMed: 29749759
WoS: 000433568500005
Scopus: 2-s2.0-85048107643
URI
https://www.future-science.com/doi/10.4155/fmc-2017-0239https://radar.ibiss.bg.ac.rs/handle/123456789/3086