Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
2018
Аутори:
Nenadić, MarijaSoković, Marina
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Ćirić, Ana
Vesović, Nikola
Ćurčić, Srećko
Тип документа:
Чланак у часопису (Рецензирана верзија)
,
© 2018 Institute of Zoology, Slovak Academy of Sciences
Метаподаци
Приказ свих података о документуАпстракт:
Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study. The sulphorhodamine B (SRB) assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasis is put on the secretion of Abax parallelepipedus, which showed the highest antitumour potential and weakest inhibition of non-tumour cell proliferation. The antitumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time. It is suggested that certain organic acids are responsible for the action. Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity.
Напомена:
This is a post-peer-review, pre-copyedit version of an article published in Biologia. The final authenticated version is available online at: http://dx.doi.org/10.2478/s11756-018-0082-x
Кључне речи:
Pygidial gland secretions; Ground beetles; Antiproliferative effect; Cell lines; EllipticineИзвор:
Biologia, 2018Финансирање / пројекти:
- Онтогенетска карактеризација филогеније биоразноврсности (RS-MESTD-Basic Research (BR or ON)-173038)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
- Foundation for Science and Technology (FCT, Portugal) (Grant No. SFRH/BPD/68344/2010)
URI
http://link.springer.com/10.2478/s11756-018-0082-xhttps://radar.ibiss.bg.ac.rs/handle/123456789/3092