Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver.
2018
Аутори:
Milošević, Marija D.Paunović, Milica G.
Matić, Miloš M.
Ognjanović, Branka I.
Saičić, Zorica
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2018 Elsevier Masson SAS
Метаподаци
Приказ свих података о документуАпстракт:
Excessive use of organophosphate insecticides, including fenitrothion (FNT) can cause detrimental consequences in non-target organisms. Selenium (Se) and vitamin C (Vit C) possess protective abilities against various toxic compounds due to their antioxidative properties. Accordingly, the aim of the present study was to examine the possible ameliorative effects of Se and Vit C in hepatotoxicity induced by FNT. For the purpose of this study, male Wistar albino rats were divided into control and groups treated with Se (0.5 mg/kg b.w, as Na2SeO3) and Vit C (100 mg/kg b.w), FNT (20 mg/kg b.w) and FNT in cotreatment with Se and Vit C for 30 days. The current data showed a reduction in absolute and relative liver weight after FNT administration. Increased activities of liver enzymes (AST, ALT, ALP, LDH and GGT) indicated liver damage. FNT alone caused significant alterations in biochemical parameters (glucose and total bilirubin). Elevation in LPO level along with decreased activities of antioxidant enzymes (SOD, CAT, GSH-Px) and GSH content reflected the presence of oxidative stress. Coadministration of FNT with Se and Vit C exhibited hepatoprotective role confirmed by reduction of oxidative stress levels and restoration in the values of examined parameters. Because of their beneficial effects, Se and Vit C may be used in reducing injuries caused by pesticides.
Кључне речи:
Fenitrothion; Liver toxicity; Oxidative stress; Selenium; Vitamin CИзвор:
Biomedicine & Pharmacotherapy, 2018, 106, 232-238Финансирање / пројекти:
- Молекуларно физиолошки биомониторинг аеробних организама заснован на одређивању биохемијских биомаркера оксидационог стреса (RS-MESTD-Basic Research (BR or ON)-173041)
DOI: 10.1016/j.biopha.2018.06.132
PubMed: 29966965
WoS: 000442600300029
Scopus: 2-s2.0-85049101459
URI
https://www.sciencedirect.com/science/article/pii/S0753332218311636?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3100