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Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer's Disease.
dc.creator | Milanović, Desanka | |
dc.creator | Petrovic, Snjezana | |
dc.creator | Brkić, Marjana | |
dc.creator | Avramović, Vladimir | |
dc.creator | Perović, Milka | |
dc.creator | Ivković, Sanja | |
dc.creator | Glibetić, Marija | |
dc.creator | Kanazir, Selma | |
dc.date.accessioned | 2018-09-21T07:30:37Z | |
dc.date.available | 2018-09-21T07:30:37Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://www.mdpi.com/2072-6643/10/9/1250 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3136 | |
dc.description.abstract | Long-term fish oil (FO) supplementation is able to improve Alzheimer's disease (AD) pathology. We aimed to determine the impact of short-term fish oil (FO) intake on phospholipids composition and plaque pathology in 5xFAD mice, a widely used animal model of AD. A 3-week-long FO supplementation administered at 3 months of age decreased the number of dense core plaques in the 5xFAD cortex and changed phospholipids in the livers and brains of wild-type (Wt) and 5xFAD mice. Livers of both genotypes responded by increase of n-3 and reciprocal decrease of n-6 fatty acids. In Wt brains, FO supplementation induced elevation of n-3 fatty acids and subsequent enhancement of n-6/n-3 ratio. However, in 5xFAD brains the improved n-6/n-3 ratio was mainly due to FO-induced decrease in arachidonic and adrenic n-6 fatty acids. Also, brain and liver abundance of n-3 fatty acids were strongly correlated in Wts, oppositely to 5xFADs where significant brain-liver correlation exists only for n-6 fatty acids. Expression of omega-3 transporter Mfs2a remained unchanged after FO supplementation. We have demonstrated that even a short-term FO intake improves the phospholipid composition and has a significant effect on plaque burden in 5xFAD brains when applied in early stages of AD pathology. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS// | |
dc.relation | Fogarty International Research Award, NIH (R03AG046216) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Nutrients | |
dc.subject | Alzheimer’s disease | |
dc.subject | Mfsd2a | |
dc.subject | Amyloid-β | |
dc.subject | Docosahexaenoic acid | |
dc.subject | n-3 polyunsaturated fatty acids | |
dc.subject | n-6 fatty acids | |
dc.title | Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer's Disease. | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Глибетић, Марија; Петровиц, Сњезана; Бркић, Марјана; Aврамовић, Владимир; Перовић, Милка; Ивковић, Сања; Каназир, Селма; Милановић, Десанка; | |
dc.rights.holder | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.citation.issue | 9 | |
dc.citation.volume | 10 | |
dc.identifier.doi | 10.3390/nu10091250 | |
dc.identifier.pmid | 30200627 | |
dc.identifier.scopus | 2-s2.0-85053076490 | |
dc.identifier.wos | 000448659900123 | |
dc.citation.apa | Milanovic, D., Petrovic, S., Brkic, M., Avramovic, V., Perovic, M., Ivkovic, S., … Kanazir, S. (2018). Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer’s Disease. Nutrients, 10(9), 1250. | |
dc.citation.vancouver | Milanovic D, Petrovic S, Brkic M, Avramovic V, Perovic M, Ivkovic S, Glibetic M, Kanazir S. Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer’s Disease. Nutrients. 2018;10(9):1250. | |
dc.citation.spage | 1250 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/4474/Nutrients_2018_10_9_125.pdf | |
dc.citation.rank | M21 |