Sleep spindle dynamics during NREM and REM sleep following distinct general anaesthesia in control rats and in a rat model of Parkinson’s disease cholinopathy
2018
Тип документа:
Чланак у часопису (Рецензирана верзија)
,
© 2018 European Sleep Research Society
Метаподаци
Приказ свих података о документуАпстракт:
On the basis of our previous studies and the important role of the thalamo-cortical network in states of unconsciousness, such as anaesthesia and sleep, and in sleep spindles generation, we investigated sleep spindles (SS) and high-voltage sleep spindle (HVS) dynamics during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep following different types of general anaesthesia in both physiological controls and in a rat model of Parkinson's disease (PD) cholinopathy, to follow the impact of anaesthesia on post-anaesthesia sleep at the thalamo-cortical level through an altered sleep spindle dynamics. We recorded 6 hr of spontaneous sleep in all rats, both before and 48 hr after ketamine/diazepam or pentobarbital anaesthesia, and we used 1 hr of NREM or REM sleep from each to validate visually the automatically detected SS or HVS for their extraction and analysis. In the controls, SS occurred mainly during NREM, whereas HVS occurred only during REM sleep. Ketamine/diazepam anaesthesia promoted HVS, prolonged SS during NREM, induced HVS of increased frequency during REM, and increased SS/HVS densities during REM versus NREM sleep. Pentobarbital anaesthesia decreased the frequency of SS during NREM and the HVS density during REM sleep. Although the pedunculopontine tegmental nucleus lesion prolonged SS only during NREM sleep, in these rats, ketamine/diazepam anaesthesia suppressed HVS during both sleep states, whereas pentobarbital anaesthesia promoted HVS during REM sleep. The different impacts of two anaesthetic regimens on the thalamo-cortical regulatory network are expressed through their distinct sleep spindle generation and dynamics that are dependent on the NREM and REM state regulatory neuronal substrate.
Кључне речи:
High voltage sleep spindles; Ketamine/diazepam; Pentobarbital; Post-anaesthesia NREM sleep; Post-anaesthesia REM sleep; Sleep spindlesИзвор:
Journal of Sleep Research, 2018Финансирање / пројекти:
- Неуробиологија спавања у старењу и болести - електроенцефалографски маркери и моделирање у процени поремећаја (RS-MESTD-Basic Research (BR or ON)-173022)
DOI: 10.1111/jsr.12758
PubMed: 30136327
WoS: 000456255400020
Scopus: 2-s2.0-85053183459
Колекције
Институција/група
IBISSAPA:
Lazic, K., Ciric, J., & Saponjic, J. (2018). Sleep spindle dynamics during NREM and REM sleep following distinct general anaesthesia in control rats and in a rat model of Parkinson’s disease cholinopathy. Journal of Sleep Research, DOI:10.1111/jsr.12758.Vancouver:
Lazic K, Ciric J, Saponjic J. Sleep spindle dynamics during NREM and REM sleep following distinct general anaesthesia in control rats and in a rat model of Parkinson’s disease cholinopathy. J Sleep Res. 2018;DOI:10.1111/jsr.12758.Related items
Showing items related by title, author, creator and subject.
-
Alterations of Sleep and Sleep Oscillations in the Hemiparkinsonian Rat.
Ćirić, Jelena; Kapor, Slobodan; Perović, Milka; Šaponjić, Jasna (Frontiers in Neuroscience, 2019) -
Sleep spindles as an early biomarker of REM sleep disorder in a rat model of Parkinson’s disease cholinopathy
Ćirić, Jelena; Lazić, Katarina; Petrović, Jelena; Kalauzi, A; Šaponjić, Jasna (Translational Brain Rhythmicity, 2017) -
Hippocampal sleep spindle dynamics during REM sleep and their distinct underlying parvalbumin and synaptic proteins expression in the reticulo-thalamic nucleus of the parkinsonian rats
Radovanović, Ljiljana; Šaponjić, Jasna; Petrović, Jelena (Federation of European Neuroscience Societies, 2022)