Polymorphisms and haplotypes in VDR gene are associated with female idiopathic infertility
2020
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2018 The British Fertility Society
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Приказ свих података о документуАпстракт:
AbstractUnexplained infertility refers to the absence of a definable cause of reproductive failure. Vitamin D receptor (VDR) acts as a transcription factor and regulates a number of vitamin D-responsive genes, including those involved in the immune system. Recent finding that VDR is expressed in reproductive tissues suggests a possible importance of vitamin D in pregnancy. We conducted a case-control study to examine the association of polymorphisms in VDR gene with reproductive success. DNA from 117 female patients with unexplained infertility and 130 fertile controls was isolated from peripheral blood and VDR genotypes (FokI, BsmI, ApaI and TaqI) were detected by PCR-RFLP. Haplotypes were determined using Haploview software. Our results show significant association of FokI and BsmI polymorphisms with infertility (p < 0.05). The haplotype analysis confirmed strong linkage disequilibrium between closely positioned BsmI, ApaI and TaqI polymorphisms. Two haplotypes were associated with infertility: (i) hapl...
Кључне речи:
DNA polymorphisms; Idiopathic female infertility; VDR geneИзвор:
Human Fertility, 2020, 23, 2, 101-110Финансирање / пројекти:
DOI: 10.1080/14647273.2018.1515503
ISSN: 1464-7273
PubMed: 30221569
WoS: 000544432500005
Scopus: 2-s2.0-85053449496
URI
https://www.tandfonline.com/doi/full/10.1080/14647273.2018.1515503https://radar.ibiss.bg.ac.rs/handle/123456789/3141