Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
2017
Authors:
Katanić, JelenaMatić, Sanja
Pferschy-Wenzig, Eva-Maria
Kretschmer, Nadine
Boroja, Tatjana
Mihailović, Vladimir
Stanković, Vesna
Stanković, Nevena
Mladenović, Milan
Stanić, Snežana
Mihailović, Mirjana
Bauer, Rudolf
Document Type:
Article (Published version)
,
© 2016 Elsevier Ltd
Metadata
Show full item recordAbstract:
Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.
Keywords:
Cisplatin; Cytotoxicity; Filipendula ulmaria; Genotoxicity; LC-DAD-MS(n) analysis; Oxidative stressSource:
Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association, 2017, 99, 86-102Funding / projects:
- Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Preclinical investigation of bioactive substances (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41010)
- Scholarship Foundation of the Republic of Austria and the Austrian Agency for International Cooperation in Education and Research (OeAD) ICM–2014-07003.
DOI: 10.1016/j.fct.2016.11.018
ISSN: 0278-6915
PubMed: 27871982
WoS: 000392789800009
Scopus: 2-s2.0-85002157867
URI
https://www.sciencedirect.com/science/article/pii/S0278691516304343?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3178