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Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis.
dc.creator | Katanić, Jelena | |
dc.creator | Matić, Sanja | |
dc.creator | Pferschy-Wenzig, Eva-Maria | |
dc.creator | Kretschmer, Nadine | |
dc.creator | Boroja, Tatjana | |
dc.creator | Mihailović, Vladimir | |
dc.creator | Stanković, Vesna | |
dc.creator | Stanković, Nevena | |
dc.creator | Mladenović, Milan | |
dc.creator | Stanić, Snežana | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Bauer, Rudolf | |
dc.date.accessioned | 2018-11-15T09:39:39Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0278691516304343?via%3Dihub | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3178 | |
dc.description.abstract | Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC50 > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41010/RS// | |
dc.relation | Scholarship Foundation of the Republic of Austria and the Austrian Agency for International Cooperation in Education and Research (OeAD) ICM–2014-07003. | |
dc.rights | restrictedAccess | |
dc.source | Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association | |
dc.subject | Cisplatin | |
dc.subject | Cytotoxicity | |
dc.subject | Filipendula ulmaria | |
dc.subject | Genotoxicity | |
dc.subject | LC-DAD-MS(n) analysis | |
dc.subject | Oxidative stress | |
dc.title | Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Станковић, Невена; Станић, Снежана; Михаиловић, Мирјана; Пферсцхy-Wензиг, Ева-Мариа; Кретсцхмер, Надине; Младеновић, Милан; Бауер, Рудолф; Катанић, Јелена; Матић, Сања; Бороја, Татјана; Михаиловић, Владимир; Станковић, Весна; | |
dc.rights.holder | © 2016 Elsevier Ltd | |
dc.citation.volume | 99 | |
dc.identifier.doi | 10.1016/j.fct.2016.11.018 | |
dc.identifier.pmid | 27871982 | |
dc.identifier.scopus | 2-s2.0-85002157867 | |
dc.identifier.wos | 000392789800009 | |
dc.citation.apa | Katanić, J., Matić, S., Pferschy-Wenzig, E.-M., Kretschmer, N., Boroja, T., Mihailović, V., … Bauer, R. (2017). Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 99, 86–102. | |
dc.citation.vancouver | Katanić J, Matić S, Pferschy-Wenzig E-M, Kretschmer N, Boroja T, Mihailović V, Stanković V, Stanković N, Mladenović M, Stanić S, Mihailović M, Bauer R. Filipendula ulmaria extracts attenuate cisplatin-induced liver and kidney oxidative stress in rats: In vivo investigation and LC-MS analysis. Food Chem Toxicol. 2017;99:86–102. | |
dc.citation.spage | 86 | |
dc.citation.epage | 102 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |