β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms
2013
Аутори:
Mihailović, MirjanaArambašić Jovanović, Jelena
Uskoković, Aleksandra
Dinić, Svetlana
Grdović, Nevena
Marković, Jelena
Mujić, Ibrahim
Šijački, Ana D.
Poznanović, Goran
Vidaković, Melita
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications.
Кључне речи:
β-Glucan; Akt kinase; Antioxidant activities; Diabetes; Pro-survival pathwaysИзвор:
Journal of Functional Foods, 2013, 5, 1, 267-278Финансирање / пројекти:
- Сигнални молекули у дијабетесу: идентификација потенцијалних биолошких маркера укључених у модификацију и интеграцију сигналних путева у циљу предикције и интервенције у дијабетесу (RS-MESTD-Basic Research (BR or ON)-173020)
DOI: 10.1016/j.jff.2012.10.016
ISSN: 1756-4646