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β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms
dc.creator | Mihailović, Mirjana | |
dc.creator | Arambašić Jovanović, Jelena | |
dc.creator | Uskoković, Aleksandra | |
dc.creator | Dinić, Svetlana | |
dc.creator | Grdović, Nevena | |
dc.creator | Marković, Jelena | |
dc.creator | Mujić, Ibrahim | |
dc.creator | Šijački, Ana D. | |
dc.creator | Poznanović, Goran | |
dc.creator | Vidaković, Melita | |
dc.date.accessioned | 2018-11-26T13:57:09Z | |
dc.date.available | 2018-11-26T13:57:09Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | http://search.crossref.org/?q=10.1016%2Fj.jff.2012.10.016+ | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S1756464612001624 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3183 | |
dc.description.abstract | The mechanisms underlying the beneficial effect observed in diabetic rats after treatment with a commercially available β-glucan-enriched extract (BGEE) were examined. Multiple low-dose streptozotocin (STZ) diabetes was used (40 mg STZ/kg) as a model for type 1 diabetes. BGEE was administered daily (80 mg/kg) for 4 weeks, starting from the last day of the STZ treatment. In vitro and in vivo experiments suggest that significant free radical scavenging and antioxidant activities of BGEE were responsible for a systemic adjustment of the redox disturbance and reduction of DNA damage in the liver and kidney of diabetic rats. BGEE-treated diabetic rats also displayed increased Akt kinase activity and decreased pro-caspase-3 degradation, implying that BGEE mediates its beneficial effects through activation of the cellular pro-survival pathway. We conclude that β-glucan administration under diabetic conditions promotes a systemic improvement that can be expected to increase the organism’s resistance to the onset of diabetic complications. | en |
dc.language | en | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Functional Foods | |
dc.subject | β-Glucan | |
dc.subject | Akt kinase | |
dc.subject | Antioxidant activities | |
dc.subject | Diabetes | |
dc.subject | Pro-survival pathways | |
dc.title | β-Glucan administration to diabetic rats reestablishes redox balance and stimulates cellular pro-survival mechanisms | en |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Шијачки, Aна Д.; Михаиловић, Мирјана; Aрамбашић, Јелена; Ускоковић, Aлександра; Динић, Светлана; Грдовић, Невена; Мујић, Ибрахим; Познановић, Горан; Видаковић, Мелита; Марковић, Јелена; | |
dc.rights.holder | © 2012 Elsevier Ltd. | |
dc.citation.issue | 1 | |
dc.citation.volume | 5 | |
dc.identifier.doi | 10.1016/j.jff.2012.10.016 | |
dc.identifier.scopus | 2-s2.0-84873270707 | |
dc.identifier.wos | 000315241500033 | |
dc.citation.spage | 267 | |
dc.citation.epage | 278 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/14624/1-s2.0-S1756464612001624-main.pdf | |
dc.citation.rank | aM21 |