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CXC Chemokine Ligand 12 Protects Pancreatic β-Cells from Necrosis through Akt Kinase-Mediated Modulation of Poly(ADP-ribose) Polymerase-1 Activity
dc.creator | Grdović, Nevena | |
dc.creator | Dinić, Svetlana | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Uskoković, Aleksandra | |
dc.creator | Arambašić Jovanović, Jelena | |
dc.creator | Poznanović, Goran | |
dc.creator | Wagner, Ludwig | |
dc.creator | Vidaković, Melita | |
dc.creator | Cohen-Armon, Malka | |
dc.date.accessioned | 2018-11-26T14:01:54Z | |
dc.date.available | 2018-11-26T14:01:54Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://dx.plos.org/10.1371/journal.pone.0101172 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3184 | |
dc.description.abstract | The diabetes prevention paradigm envisages the application of strategies that support the maintenance of appropriate β-cell numbers. Herein we show that overexpression of CXC chemokine ligand12 (CXCL12) considerably improves the viability of isolated rat Langerhans islet cells and Rin-5F pancreatic β-cells after hydrogen peroxide treatment. In rat islets and wt cells hydrogen peroxide treatment induced necrotic cell death that was mediated by the rapid and extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1). In contrast, CXCL12-overexpressing cells were protected from necrotic cell death as a result of significantly reduced PARP-1 activity. CXCL12 downstream signalling through Akt kinase was responsible for the reduction of PARP-1 activity which switched cell death from necrosis to apoptosis, providing increased protection to cells from oxidative stress. Our results offer a novel aspect of the CXCL12-mediated improvement of β-cell viability which is based on its antinecrotic action through modulation of PARP-1 activity. | en |
dc.publisher | San Francisco: Public Library of Science | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | PLOS One | |
dc.title | CXC Chemokine Ligand 12 Protects Pancreatic β-Cells from Necrosis through Akt Kinase-Mediated Modulation of Poly(ADP-ribose) Polymerase-1 Activity | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Михаиловић, Мирјана; Грдовић, Невена; Динић, Светлана; Ускоковић, Aлександра; Aрамбашић Јовановић, Јелена; Познановић, Горан; Видаковић, Мелита; Wагнер, Лудwиг; Цохен-Aрмон, Малка; | |
dc.rights.holder | © 2014 Grdovićet al. | |
dc.citation.issue | 7 | |
dc.citation.volume | 9 | |
dc.identifier.doi | 10.1371/journal.pone.0101172 | |
dc.identifier.pmid | 24988468 | |
dc.identifier.scopus | 2-s2.0-84903760208 | |
dc.identifier.wos | 000341354100067 | |
dc.citation.spage | e101172 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |