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Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats
dc.creator | Uskoković, Aleksandra | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Dinić, Svetlana | |
dc.creator | Arambašić Jovanović, Jelena | |
dc.creator | Grdović, Nevena | |
dc.creator | Marković, Jelena | |
dc.creator | Poznanović, Goran | |
dc.creator | Vidaković, Melita | |
dc.date.accessioned | 2018-11-26T14:08:28Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S175646461300217X | |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S175646461300217X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3187 | |
dc.description.abstract | The beneficial effect of a commercially available β-glucan-enriched extract (BGEE) from cereal grain, against a diabetes-induced hepatic redox imbalance and inflammatory response in streptozotocin-induced diabetic rats was evaluated. Diabetic rats that were treated with BGEE exhibited lower hyperglycaemia and improved biochemical parameters of liver damage. BGEE attenuated hepatic oxidative stress, revealed by a decreased concentration of thiobarbituric acid reactive substances and a restored GSH/GSSG ratio. BGEE also exerted an anti-inflammatory effect on the liver, evidenced by the normalization of the serum concentrations of the "positive" and "negative" acute-phase proteins, α2-macroglobulin and albumin, respectively, as well as by upregulation of anti-inflammatory cytokine IL-10 and IL-4 mRNA expression, and inhibition of RAGE/NF-κB signaling. These findings suggest that BGEE application exerts a beneficial effect in the liver of streptozotocin-induced diabetic rats via its antioxidant and anti-inflammatory activities, and that it therefore possesses an important potential in diabetes management. © 2013 Elsevier Ltd. | en |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Functional Foods | |
dc.subject | Acute-phase proteins | |
dc.subject | Diabetes | |
dc.subject | Inflammation | |
dc.subject | Liver | |
dc.subject | Oxidative stress | |
dc.subject | β-Glucan | |
dc.title | Administration of a β-glucan-enriched extract activates beneficial hepatic antioxidant and anti-inflammatory mechanisms in streptozotocin-induced diabetic rats | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Ускоковић, Aлександра; Михаиловић, Мирјана; Динић, Светлана; Aрамбашић Јовановић, Јелена; Грдовић, Невена; Марковић, Јелена; Познановић, Горан; Видаковић, Мелита; | |
dc.rights.holder | © 2013 Elsevier Ltd. | |
dc.citation.issue | 4 | |
dc.citation.volume | 5 | |
dc.identifier.doi | 10.1016/j.jff.2013.09.018 | |
dc.identifier.scopus | 2-s2.0-84888428125 | |
dc.identifier.wos | 000340737100048 | |
dc.citation.spage | 1966 | |
dc.citation.epage | 1974 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |