Приказ основних података о документу

dc.creatorLazarević, Milica
dc.creatorMazzon, Emanuela
dc.creatorMomčilović, Miljana
dc.creatorBasile, Maria Sofia
dc.creatorColletti, Giuseppe
dc.creatorPetralia, Maria Cristina
dc.creatorBramanti, Placido
dc.creatorNicoletti, Ferdinando
dc.creatorMiljković, Đorđe
dc.date.accessioned2018-12-05T10:30:20Z
dc.date.available2018-12-05T10:30:20Z
dc.date.issued2018
dc.identifier.urihttp://www.mdpi.com/1420-3049/23/11/2966
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/3191
dc.description.abstractGYY4137 is a hydrogen sulfide (H₂S) donor that has been shown to act in an anti-inflammatory manner in vitro and in vivo. Microglial cells are among the major players in immunoinflammatory, degenerative, and neoplastic disorders of the central nervous system, including multiple sclerosis, Parkinson's disease, Alzheimer's disease, and glioblastoma multiforme. So far, the effects of GYY4137 on microglial cells have not been thoroughly investigated. In this study, BV2 microglial cells were stimulated with interferon-gamma and lipopolysaccharide and treated with GYY4137. The agent did not influence the viability of BV2 cells in concentrations up to 200 μM. It inhibited tumor necrosis factor but not interleukin-6 production. Expression of CD40 and CD86 were reduced under the influence of the donor. The phagocytic ability of BV2 cells and nitric oxide production were also affected by the agent. Surprisingly, GYY4137 upregulated generation of reactive oxygen species (ROS) by BV2 cells. The effect was mimicked by another H₂S donor, Na₂S, and it was not reproduced in macrophages. Our results demonstrate that GYY4137 downregulates inflammatory properties of BV2 cells but increases their ability to generate ROS. Further investigation of this unexpected phenomenon is warranted.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.rightsopenAccess
dc.sourceMolecules (Basel, Switzerland)
dc.subjectGYY4137
dc.subjectHydrogen sulfide
dc.subjectInflammation
dc.subjectMicroglia
dc.subjectReactive oxygen species
dc.titleThe H₂S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide.en
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractБраманти, Плацидо; Момчиловић, Миљана; Ницолетти, Фердинандо; Миљковић, Ђорђе; Лазаревић, Милица; Маззон, Емануела; Басиле, Мариа Софиа; Цоллетти, Гиусеппе; Петралиа, Мариа Цристина;
dc.rights.holder© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.citation.issue11
dc.citation.volume23
dc.identifier.doi10.3390/molecules23112966
dc.identifier.pmid30441775
dc.identifier.scopus2-s2.0-85056508830
dc.identifier.wos000451641900238
dc.citation.vancouverLazarević M, Mazzon E, Momčilović M, Basile MS, Colletti G, Petralia MC, Bramanti P, Nicoletti F, Miljković Đ. The H₂S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide. Molecules. 2018;23(11):2966.
dc.citation.vancouverLazarević, M., Mazzon, E., Momčilović, M., Basile, M. S., Colletti, G., Petralia, M. C., … Miljković, Đ. (2018). The H₂S Donor GYY4137 Stimulates Reactive Oxygen Species Generation in BV2 Cells While Suppressing the Secretion of TNF and Nitric Oxide. Molecules (Basel, Switzerland), 23(11), 2966.
dc.citation.spage2966
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttps://radar.ibiss.bg.ac.rs//bitstream/id/4619/Molecules_2018_23_11_2966.pdf
dc.citation.rankM21


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу