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Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells
dc.creator | Mujić, Aida | |
dc.creator | Grdović, Nevena | |
dc.creator | Mujić, Ibrahim | |
dc.creator | Mihailović, Mirjana | |
dc.creator | Živković, Jelena | |
dc.creator | Poznanović, Goran | |
dc.creator | Vidaković, Melita | |
dc.date.accessioned | 2018-12-12T12:12:51Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0308-8146 | |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-78149407400&partnerID=tZOtx3y1 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3203 | |
dc.description.abstract | Oxidative stress plays a central role in the onset of diabetes which is characterised by progressive pancreatic β-cell failure. We studied the ability of phenolic extracts prepared from chestnut leaf, catkin and spiny burs to prevent oxidative stress-induced β-cell (Rin-5F) death. The Rin-5F cell death was induced by treatment with the diabetogenic agent streptozotocin (STZ) and the protective effects of the chestnut extracts were assessed after cells treatment with a STZ/extracts mixture. The chestnut extracts increased cell viability by protecting DNA from oxidative damage and by enhancing the natural antioxidant system. Moreover, the chestnut extracts had a significant impact on the cell's redox-status which was observed as an increase in the levels of reduced glutathione. Chestnut extracts were capable of inhibiting lipid peroxidation, which was manifested as a lowering of malondialdehyde levels. We concluded that chestnut extracts increased cell viability after STZ treatment as a result of their antioxidative properties. © 2010 Elsevier Ltd. | en |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143002/RS// | |
dc.rights | restrictedAccess | |
dc.source | Food Chemistry | |
dc.subject | Antioxidative activity | |
dc.subject | Cell death | |
dc.subject | DNA damage | |
dc.subject | Oxidative stress | |
dc.subject | Phenolic-rich chestnut extracts | |
dc.title | Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Грдовић, Невена; Мујић, Aида; Мујић, Ибрахим; Михаиловић, Мирјана; Живковић, Јелена; Познановић, Горан; Видаковић, Мелита; | |
dc.rights.holder | © 2010 Elsevier Ltd. | |
dc.citation.issue | 3 | |
dc.citation.volume | 125 | |
dc.identifier.doi | 10.1016/j.foodchem.2010.08.068 | |
dc.identifier.scopus | 2-s2.0-78149407400 | |
dc.identifier.wos | 000284818400005 | |
dc.citation.spage | 841 | |
dc.citation.epage | 849 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |