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Genotoxic potential of Cotinus coggygriascop. (Anacardiaceae) stem extract in vivo
dc.creator | Matić, Sanja | |
dc.creator | Stanić, Snećana | |
dc.creator | Bogojević, Desanka | |
dc.creator | Solujić, Slavica | |
dc.creator | Grdović, Nevena | |
dc.creator | Vidaković, Melita | |
dc.creator | Mihailović, Mirjana | |
dc.date.accessioned | 2018-12-12T12:25:03Z | |
dc.date.available | 2018-12-12T12:25:03Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1415-4757 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3205 | |
dc.description.abstract | The intention was to evaluate the possible in vivo genotoxic potential in different cell-types, of a methanol extract obtained from the plant stem of Cotinus coggygria Scop., using the sex-linked recessive lethal (or SLRL) test and alkaline comet assay. The SLRL test, revealed the genotoxic effect of this extract in postmeiotic and premeiotic germ-cell lines. The comet assay was carried out on rat liver and bone marrow at 24 and 72 h after intraperitoneal administration. For genotoxic evaluation, three concentrations of the extract were tested, viz., 500, 1000 and 2000 mg/kg body weight (bw), based on the solubility limit of the extract in saline. Comet tail moment and total scores in the group treated with 500 mg/kg bw, 24 and 72 h after treatment, were not significantly different from the control group, whereas in the groups of animals, under the same conditions, but with 1000 and 2000 mg/kg bw of the extract, scores were statistically so. A slight decrease in the comet score and tail moment observed in all the doses in the 72 h treatment, gave to understand that DNA damage induced by Cotinus coggygria extract decreased with time. The results of both tests revealed the genotoxic effect of Cotinus coggygria under our experimental conditions. | en |
dc.publisher | Sociedade Brasileira de Genética | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Genetics and Molecular Biology | |
dc.subject | Comet assay | |
dc.subject | Cotinus coggygria | |
dc.subject | Extract | |
dc.subject | Genotoxic effect | |
dc.subject | SLRL | |
dc.title | Genotoxic potential of Cotinus coggygriascop. (Anacardiaceae) stem extract in vivo | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Богојевић, Десанка; Солујић, Славица; Грдовић, Невена; Видаковић, Мелита; Михаиловић, Мирјана; Матић, Сања; Станић, Снећана; | |
dc.rights.holder | © 2011, Sociedade Brasileira de Genética. Printed in Brazil. | |
dc.citation.issue | 2 | |
dc.citation.volume | 34 | |
dc.identifier.doi | 10.1590/S1415-47572011005000001 | |
dc.identifier.pmid | 21734833 | |
dc.identifier.scopus | 2-s2.0-79957897184 | |
dc.identifier.wos | 000290865300022 | |
dc.citation.spage | 298 | |
dc.citation.epage | 303 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/14583/document.pdf | |
dc.citation.rank | M23 |