dc.creator | Basile, Maria Sofia | |
dc.creator | Mazzon, Emanuela | |
dc.creator | Krajnović, Tamara | |
dc.creator | Drača, Dijana | |
dc.creator | Cavalli, Eugenio | |
dc.creator | Al-Abed, Yousef | |
dc.creator | Bramanti, Placido | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.date.accessioned | 2018-12-25T13:25:00Z | |
dc.date.available | 2018-12-25T13:25:00Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | internal-pdf://Basile et al. - 2018 - Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells.pdf | |
dc.identifier.uri | http://www.mdpi.com/1420-3049/23/10/2463 | |
dc.identifier.uri | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6222694 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3216 | |
dc.description.abstract | Glioblastoma (GBM) is the most frequent and deadly form of primary malignant brain tumor among adults. A promising emerging approach for GBM treatment may be offered from HIV protease inhibitors (HIV-PIs). In fact, in addition to their primary pharmacological activity in the treatment of HIV infection, they possess important anti-neoplastic effects. According to previous studies, the addition of a nitric oxide (NO) donating group to parental compounds can reduce their toxicity and enhance the anticancer action of various compounds, including HIV-PIs. In this study we compared the effects of the HIV-PI Lopinavir (Lopi) and of its NO-derivative Lopinavir-NO (Lopi-NO) on the in vitro growth of LN-229 and U-251 human GBM cell lines. Lopi-NO reduced the viability of LN-229 and U-251 cells at significantly lower concentrations than the parental drug. In particular, Lopi-NO inhibited tumor cell proliferation and induced the differentiation of U-251 cells toward an astrocyte-like phenotype without triggering significant cell death in both cell types. The anticancer effect of Lopi-NO was persistent even upon drug removal. Furthermore, Lopi-NO induced strong autophagy that did not appear to be related to its chemotherapeutic action. Overall, our results suggest that Lopi-NO could be a potential effective anticancer drug for GBM treatment. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Molecules (Basel, Switzerland) | |
dc.source | Molecules (Basel, Switzerland) | |
dc.subject | HIV protease inhibitors | |
dc.subject | Lopinavir | |
dc.subject | Lopinavir-NO | |
dc.subject | Glioblastoma | |
dc.subject | Nitric oxide | |
dc.title | Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells. | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Aл-Aбед, Yоусеф; Маззон, Емануела; Басиле, Мариа Софиа; Драча, Дијана; Цавалли, Еугенио; Браманти, Плацидо; Ницолетти, Фердинандо; Крајновић, Тамара; Мијатовић, Сања; Максимовић-Иванић, Данијела; | |
dc.rights.holder | © 2018 by the authors. | |
dc.citation.issue | 10 | |
dc.citation.volume | 23 | |
dc.identifier.doi | 10.3390/molecules23102463 | |
dc.identifier.pmid | 30261624 | |
dc.identifier.scopus | 2-s2.0-85054082968 | |
dc.identifier.wos | 000451201400059 | |
dc.citation.apa | Basile, M. S., Mazzon, E., Krajnovic, T., Draca, D., Cavalli, E., Al-Abed, Y., … Maksimovic-Ivanic, D. (2018). Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells. Molecules (Basel, Switzerland), 23(10), 2463. | |
dc.citation.vancouver | Basile MS, Mazzon E, Krajnovic T, Draca D, Cavalli E, Al-Abed Y, Bramanti P, Nicoletti F, Mijatovic S, Maksimovic-Ivanic D. Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells. Molecules. 2018;23(10):2463. | |
dc.citation.spage | 2463 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/4659/Molecules_2018_23_10_2463.pdf | |
dc.citation.rank | M21 | |