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Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells.

dc.creatorKuhnert, Robert
dc.creatorSárosi, Menyhárt-Botond
dc.creatorGeorge, Sven
dc.creatorLönnecke, Peter
dc.creatorHofmann, Bettina
dc.creatorSteinhilber, Dieter
dc.creatorSteinmann, Sara
dc.creatorSchneider-Stock, Regine
dc.creatorMurganić, Blagoje
dc.creatorMijatović, Sanja
dc.creatorMaksimović-Ivanić, Danijela
dc.creatorHey-Hawkins, Evamarie
dc.date.accessioned2019-01-11T13:32:51Z
dc.date.available2019-01-11T13:32:51Z
dc.date.issued2018
dc.identifier.urihttp://doi.wiley.com/10.1002/cmdc.201800651
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/3225
dc.description.abstract5-Lipoxygenase converts arachidonic acid into leukotrienes, which are involved in inflammation and angiogenesis. The introduction of carboranes can improve the pharmacokinetic behavior of metabolically less stable pharmaceutics. Herein we report the syntheses of several carborane-based inhibitors of the 5-lipoxygenase pathway. The isosteric replacement of phenyl rings by carboranes leads to improved cytotoxicity toward several melanoma and colon cancer cell lines. For the colon cancer cell line HCT116, the co-inhibition of heat shock protein 90 was observed.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationDFG. Grant Numbers: SFB 1039, HE 1376/38-1, SA 2902/2-1
dc.rightsrestrictedAccess
dc.sourceChemMedChem
dc.sourceChemMedChem
dc.subjectCancer
dc.subjectCarboranes
dc.subjectHeat shock protein 90
dc.subjectInhibitors
dc.subjectLipoxygenase
dc.titleCarborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells.en
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractМијатовић, Сања; Кухнерт, Роберт; Сáроси, Менyхáрт-Ботонд; Георге, Свен; Лöннецке, Петер; Хофманн, Беттина; Стеинхилбер, Диетер; Мурганић, Благоје; Хеy-Хаwкинс, Евамарие; Максимовић-Иванић, Данијела; Стеинманн, Сара; Сцхнеидер-Стоцк, Регине;
dc.rights.holder© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.identifier.doi10.1002/cmdc.201800651
dc.identifier.pmid30471171
dc.identifier.scopus2-s2.0-85058963395
dc.identifier.wos000456749200005
dc.citation.apaKuhnert, R., Sárosi, M.-B., George, S., Lönnecke, P., Hofmann, B., Steinhilber, D., … Hey-Hawkins, E. (2018). Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells. ChemMedChem, DOI:10.1002/cmdc.201800651.
dc.citation.vancouverKuhnert R, Sárosi M-B, George S, Lönnecke P, Hofmann B, Steinhilber D, Steinmann S, Schneider-Stock R, Murganić B, Mijatović S, Maksimović-Ivanić D, Hey-Hawkins E. Carborane-Based Analogues of 5-Lipoxygenase Inhibitors Co-inhibit Heat Shock Protein 90 in HCT116 Cells. ChemMedChem. 2018;DOI:10.1002/cmdc.201800651.
dc.type.versionacceptedVersion
dc.citation.rankM21


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