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Deficiency of macrophage migration inhibitory factor (MIF) inhibits cytokine-induced IL-1β generation in murine pancreatic islet cells
dc.creator | Stojanović, Ivana D. | |
dc.creator | Saksida, Tamara | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.date.accessioned | 2015-08-28T10:26:51Z | |
dc.date.available | 2015-08-28T10:26:51Z | |
dc.date.issued | 2013 | |
dc.date.issued | 2013 | sr |
dc.identifier.issn | 0354-4664 | sr |
dc.identifier.other | Rad_konverzija_381 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/324 | |
dc.description.abstract | In diabetes, pancreatic islets are subjected to high levels of inflammatory mediators that can lead to beta cell destruction. We recently showed that pancreatic islet cells derived from MIF-deficient (MIF-KO) mice are resistant to apoptosis induction by the cytotoxic stimuli of cytokines. Here we show that MIF-KO islets under cytokine (IFN-γ+TNF- α+IL-1β) stimulation express and secrete significantly lower amounts of IL-1β, while the expression of caspase-1 mRNA is not influenced by MIF deficiency. These data suggest that MIF-KO islets possess an innate defect in the process of IL-1 β synthesis and secretion. | en |
dc.description.sponsorship | null | sr |
dc.language.iso | eng | sr |
dc.rights | openAccess | sr |
dc.source | Archives of Biological Sciences | sr |
dc.subject | Pancreatic islets | ENG |
dc.subject | Macrophage Migration Inhibitory Factor (MIF) | ENG |
dc.subject | IL-1β | ENG |
dc.subject | caspase-1 | ENG |
dc.title | Deficiency of macrophage migration inhibitory factor (MIF) inhibits cytokine-induced IL-1β generation in murine pancreatic islet cells | en |
dc.type | article | sr |
dc.rights.license | ARR | |
dcterms.abstract | Стошић-Грујичић, Станислава Д.; Саксида, Тамара; Стојановић, Ивана; | |
dc.citation.issue | 1 | sr |
dc.citation.volume | 65 | sr |
dc.citation.spage | 9 | sr |
dc.citation.epage | 15 | sr |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/2434/Rad_konverzija_381.pdf | |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_324 |