Novel antimicrobial agents' discovery among the steroid derivatives.
2019
Аутори:
Nadaraia, Nanuli Sh.Amiranashvili, Lela Sh.
Merlani, Maia
Kakhabrishvili, Meri L.
Barbakadze, Nana N.
Geronikaki, Athina
Petrou, Anthi
Poroikov, Vladimir
Ćirić, Ana
Glamočlija, Jasmina
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2019 Published by Elsevier Inc.
Метаподаци
Приказ свих података о документуАпстракт:
Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/-p-chlorophenyl-3/-methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0.003-0.96 mg/mL and MFC at 0.006-1.92 mg/mL but with different sensitivity against fungi tested. According to docking studies 14-alpha demethylase inhibition may be responsible for antifungal activity. Prediction of toxicity by PROTOX and GUSAR revealed that compounds have low toxicity and can be considered as potential lead compounds for the further studies.
Кључне речи:
Antibacterial; Antifungal; N-containing 5α-steroids; Open TOX; PASSИзвор:
Steroids, 2019, 144, 52-65Финансирање / пројекти:
- University of KwaZulu-Natal (UKZN), Pietermaritzburg campus, South Africa
DOI: 10.1016/j.steroids.2019.02.012
PubMed: 30776376
WoS: 000435062900027
Scopus: 2-s2.0-85061698035
URI
https://www.sciencedirect.com/science/article/pii/S0039128X19300376?via%3Dihubhttps://radar.ibiss.bg.ac.rs/handle/123456789/3274