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Novel antimicrobial agents' discovery among the steroid derivatives.
dc.creator | Nadaraia, Nanuli Sh. | |
dc.creator | Amiranashvili, Lela Sh. | |
dc.creator | Merlani, Maia | |
dc.creator | Kakhabrishvili, Meri L. | |
dc.creator | Barbakadze, Nana N. | |
dc.creator | Geronikaki, Athina | |
dc.creator | Petrou, Anthi | |
dc.creator | Poroikov, Vladimir | |
dc.creator | Ćirić, Ana | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Soković, Marina | |
dc.date.accessioned | 2019-02-28T12:29:25Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0039128X19300376?via%3Dihub | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3274 | |
dc.description.abstract | Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/-p-chlorophenyl-3/-methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0.003-0.96 mg/mL and MFC at 0.006-1.92 mg/mL but with different sensitivity against fungi tested. According to docking studies 14-alpha demethylase inhibition may be responsible for antifungal activity. Prediction of toxicity by PROTOX and GUSAR revealed that compounds have low toxicity and can be considered as potential lead compounds for the further studies. | en |
dc.relation | University of KwaZulu-Natal (UKZN), Pietermaritzburg campus, South Africa | |
dc.rights | restrictedAccess | |
dc.source | Steroids | |
dc.subject | Antibacterial | |
dc.subject | Antifungal | |
dc.subject | N-containing 5α-steroids | |
dc.subject | Open TOX | |
dc.subject | PASS | |
dc.title | Novel antimicrobial agents' discovery among the steroid derivatives. | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Ћирић, Aна; Надараиа, Нанули Сх.; Какхабрисхвили, Мери Л.; Барбакадзе, Нана Н.; Гламочлија, Јасмина; Соковић, Марина; Aмиранасхвили, Лела Сх.; Мерлани, Маиа; Пороиков, Владимир; Героникаки, Aтхина; Петроу, Aнтхи; | |
dc.rights.holder | © 2019 Published by Elsevier Inc. | |
dc.citation.volume | 144 | |
dc.identifier.doi | 10.1016/j.steroids.2019.02.012 | |
dc.identifier.pmid | 30776376 | |
dc.identifier.scopus | 2-s2.0-85061698035 | |
dc.identifier.wos | 000435062900027 | |
dc.citation.apa | Nadaraia, N. S., Amiranashvili, L. S., Merlani, M., Kakhabrishvili, M. L., Barbakadze, N. N., Geronikaki, A., … Sokovic, M. (2019). Novel antimicrobial agents’ discovery among the steroid derivatives. Steroids, 144, 52–65. | |
dc.citation.vancouver | Nadaraia NS, Amiranashvili LS, Merlani M, Kakhabrishvili ML, Barbakadze NN, Geronikaki A, Petrou A, Poroikov V, Ciric A, Glamoclija J, Sokovic M. Novel antimicrobial agents’ discovery among the steroid derivatives. Steroids. 2019;144:52–65. | |
dc.citation.spage | 52 | |
dc.citation.epage | 65 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 |