The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol
2018
Autori:
Radić, IvanNestorović, Vojkan
Mijović, Milica
Tatalović, Nikola
Joksimović, Bojan
Lukić, Vera
Mitić, Miloš
Adžić, Miroslav
Blagojević, Duško
Veličković, Stefan
Bulajić, Sonja
Đerković, Branislav
Mirić, Mirjana
Janićijević-Hudomal, Snežana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, triglycerides, total cholesterol, HDL, LDL, VLDL, triglyceride/HDL ratio, total cholesterol/HDL ratio (cholesterol ratio) and LDL/HDL ratio (index of atherosclerosis) were determined in rats after six weeks of treatment with: (i) ethanol (12% ethanol, ad libitum), (ii) whey (2 g/kg per day), (iii) pumpkin seed oil (2 mL/kg per day), (iv) both ethanol and whey, and (v) both ethanol and pumpkin seed oil. The results showed no changes in the levels of AST, ALT, total bilirubin, ALP, total cholesterol, HDL and VLDL in alcoholic rats when compared to the controls (fed with a standard laboratory diet ad libitum) and rats supplemented with whey and pumpkin seed oil. Our results suggest that alcohol consumption in small doses for 6 weeks changes lipid metabolism and significantly elevates the LDL/HDL ratio (index of atherosclerosis) but does not induce extensive liver damage. Ethanol consumption in our experimental conditions lowered the triglyceride level as well as the triglyceride/HDL ratio, suggesting lipid redistribution and the induction of some cardio-protective effect. However, ethanol induced a higher index of atherosclerosis. Pumpkin seed oil showed some protective potential in alcoholic rats by lowering the total cholesterol/HDL ratio, but it elevated the LDH. Whey consumption prevented elevation of the atherosclerosis index, pointing to its protective role, probably through the redistribution of lipids. However, whey in combination with ethanol elevated LDH.
Ključne reči:
Whey protein; Pumpkin seed oil; Ethanol; Liver biomarkers; RatIzvor:
Archives of Biological Sciences, 2018, 70, 3, 531-541Finansiranje / projekti:
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-MESTD-Basic Research (BR or ON)-173014)
- Definisanje klastera molekulskih biomarkera za poboljšanu dijagnostiku i terapiju poremećaja raspoloženja (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41029)
DOI: 10.2298/ABS180320014R
ISSN: 0354-4664
WoS: 000442207900014
Scopus: 2-s2.0-85062030996
URI
http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800014Rhttps://radar.ibiss.bg.ac.rs/handle/123456789/3282