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Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH
dc.creator | Edeler, David | |
dc.creator | Drača, Dijana | |
dc.creator | Petković, Vladana | |
dc.creator | Natalio, Filipe | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Schmidt, Harry | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2019-03-27T13:30:40Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2019 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0928493118329175?via%3Dihub | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3302 | |
dc.description.abstract | Herein appropriateness of nonfunctionalized mesoporous silica nanoparticles SBA-15 and functionalized with (3-chloropropyl)triethoxysilane (→ SBA-15~Cl) and (3-aminopropyl)triethoxysilane (→ SBA-15~NH2) on delivery of physically adsorbed Ph3Sn(CH2)6OH (Sn6) is evaluated. Fluorescent nanomaterial, bearing isatoic moiety, loaded with Sn6 (→ SBA-15~NF|Sn6) was used for cellular uptake study. The fluorescent nanomaterial is efficiently acquired and distributed into the cytoplasm of the cells even after 2 h of cultivation. According to the attained data, all SBA-15 materials loaded with Sn6 diminished cellular viability in dose dependent manner while carriers alone (SBA-15, SBA-15~Cl, SBA-15~NH2) did not show cytotoxicity against B16 cells. According to the MC50 values structural modification of SBA-15 did not improve the efficacy of tested drug. While progressive apoptosis was detected upon the treatment with SBA-15|Sn6, exposure of cells to SBA-15~NH2|Sn6 revealed extinguished apoptosis in time, accompanied with lower caspase activity. This effect is probably due to triggered autophagic process under the treatment with the SBA-15~NH2|Sn6, thus opposed to apoptosis. Presented results suggested that functionalization of SBA-15 was not beneficial for the efficacy of loaded drug, thus, all of them are almost equally efficient considering loaded Sn6 content. Importantly, functionalization of SBA-15 does have an influence on the mode of action and differentiation inducing properties. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.rights | restrictedAccess | |
dc.source | Materials Science and Engineering: C | |
dc.subject | SBA-15 | |
dc.subject | Organotin(IV) compound | |
dc.subject | Apoptosis | |
dc.subject | Autophagy | |
dc.subject | Cell differentiation | |
dc.title | Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Сцхмидт, Харрy; Наталио, Филипе; Калуђеровић, Горан Н.; Еделер, Давид; Драча, Дијана; Петковић, Владана; Максимовић-Иванић, Данијела; Мијатовић, Сања; | |
dc.rights.holder | © 2019 Elsevier B.V. | |
dc.citation.volume | 100 | |
dc.identifier.doi | 10.1016/J.MSEC.2019.03.010 | |
dc.identifier.scopus | 2-s2.0-85062549711 | |
dc.identifier.wos | 000466059700031 | |
dc.citation.apa | Edeler, D., Drača, D., Petković, V., Natalio, F., Maksimović-Ivanić, D., Mijatović, S., … Kaluđerović, G. N. (2019). Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH. Materials Science and Engineering: C, 100, 315–322. | |
dc.citation.vancouver | Edeler D, Drača D, Petković V, Natalio F, Maksimović-Ivanić D, Mijatović S, Schmidt H, Kaluđerović GN. Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH. Mater Sci Eng C. 2019;100:315–22. | |
dc.citation.spage | 315 | |
dc.citation.epage | 322 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |