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The effect of simvastatin in pancreas of diabetic rats
dc.creator | Stančić, Ana | |
dc.creator | Korać, Aleksandra | |
dc.creator | Otašević, Vesna | |
dc.creator | Janković, Aleksandra | |
dc.creator | Korać, Bato | |
dc.date.accessioned | 2019-04-09T10:38:16Z | |
dc.date.available | 2019-04-09T10:38:16Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://hrana-ishrana.org/wp-content/uploads/2019/01/Hrana-i-ishrana-59-br-1.pdf | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/3318 | |
dc.description.abstract | Growing evidences suggest that statins exert several cholesterol-independent pleiotropic effects in diabetes, but there is no consensus whether they are positive or negative. To shed more light on this issue, we examined the effect of simvastatin on β-cell regeneration in a diabetic state. Diabetes was induced in male Mill Hill rats with a single alloxan dose (120 mg/kg). Both non-diabetic and diabetic groups were additionally separated into two subgroups: treated with simvastatin (5 mg/kg/day, i.g., 12 days) and control. Treatment of diabetic animals started after diabetes induction (glucose level ≥ 12 mmol/L). Our findings revealed that there is no increase in the area of insulin-immunopositive cells neither normalization of serum insulin level after simvastatin treatment of diabetic animals, although simvastatin increased nuclear immunopositivity for pancreas duodenum homeobox-1 (PDX-1) and proliferating cell nuclear antigen (PCNA). The data from this study suggest that 12-day treatment with simvastatin did not improve diabetes- induced disturbances in β-cell mass/function. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173055/RS// | |
dc.rights | openAccess | |
dc.source | Hrana i Ishrana | |
dc.subject | Statins | |
dc.subject | Diabetes | |
dc.subject | Insulin | |
dc.subject | β-cell regeneration | |
dc.title | The effect of simvastatin in pancreas of diabetic rats | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Кораћ, Бато; Оташевић, Весна; Јанковић, Aлександра; Кораћ, Aлександра; Станчић, Aна; | |
dc.rights.holder | © 2018 Društvo za ishranu Srbije | |
dc.citation.issue | 1 | |
dc.citation.volume | 59 | |
dc.citation.apa | Stančić, A., Korać, A., Otašević, V., Janković, A., & Korać, B. (2018). The effect of simvastatin in pancreas of diabetic rats. Hrana i Ishrana, 59(1), 19–25. | |
dc.citation.vancouver | Stančić A, Korać A, Otašević V, Janković A, Korać B. The effect of simvastatin in pancreas of diabetic rats. Hrana i Ishr. 2018;59(1):19–25. | |
dc.citation.spage | 19 | |
dc.citation.epage | 25 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/4942/HranaiIshrana_2018_59_1_19-25.pdf | |
dc.citation.rank | M52 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_3318 |